INT116249

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.16
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LARS) ligase activity (LARS) cytoplasm (LARS)
Anatomy Link Frequency
spinal 1
lateral recess 1
femur 1
LARS (Homo sapiens)
Pain Link Frequency Relevance Heat
Dermatone 4 94.40 High High
Pain 65 92.68 High High
Sciatica 17 91.28 High High
Arthritis 3 68.64 Quite High
Osteoarthritis 1 67.20 Quite High
Angina 3 50.00 Quite Low
epidural 5 47.20 Quite Low
pruritus 27 43.08 Quite Low
corticosteroid 13 5.00 Very Low Very Low Very Low
Acupuncture 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 106 100.00 Very High Very High Very High
Congenital Anomalies 18 99.24 Very High Very High Very High
Pathologic Constriction 3 97.92 Very High Very High Very High
Cancer 5 97.52 Very High Very High Very High
Nerve Root Compression 22 97.08 Very High Very High Very High
Scrapie 119 96.56 Very High Very High Very High
Creutzfeldt Jakob Disease 42 93.76 High High
Pain 63 92.68 High High
Prion Diseases 35 81.48 Quite High
Cv General 3 Under Development 1 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A prolapsed disc mostly causes LRS, but other causes include spinal or lateral recess stenosis, tumours or radiculitis [13, 34].
Positive_regulation (causes) of LRS in spinal associated with nerve root compression, pathologic constriction, cancer and syndrome
1) Confidence 0.39 Published 2007 Journal Eur Spine J Section Body Doc Link PMC2219647 Disease Relevance 1.08 Pain Relevance 0.29
Likelihood ratios (LRs) were calculated for each study, and pooled LRs were generated with 95% confidence intervals.
Positive_regulation (generated) of LRs
2) Confidence 0.33 Published 2004 Journal Health Technol Assess Section Body Doc Link 14754562 Disease Relevance 0.24 Pain Relevance 0
There are substantial differences between these clinical trials regarding the study population (e.g. underlying cause of LRS and mix of acute, subacute and chronic patients), control treatments, duration of follow-up, and primary outcome measures.
Positive_regulation (cause) of LRS associated with syndrome
3) Confidence 0.26 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2295266 Disease Relevance 0.43 Pain Relevance 0.22
A prolapsed disc is a frequent cause of LRS, but other causes include spinal or lateral recess stenosis, tumours and radiculitis [4,5,7,8].
Positive_regulation (cause) of LRS in lateral recess associated with nerve root compression, pathologic constriction, cancer and syndrome
4) Confidence 0.25 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC534096 Disease Relevance 0.93 Pain Relevance 0.13
A LRS rail lengthener is coupled to the first fixator using extra-long screws inserted into the shaft of the femur
Positive_regulation (coupled) of LRS in femur
5) Confidence 0.04 Published 2008 Journal Strategies Trauma Limb Reconstr Section Body Doc Link PMC2553433 Disease Relevance 0.28 Pain Relevance 0.07
There is currently no evidence that PrPd accumulation in LRS produces clinical abnormalities since antemortem tests generally detect pre-clinical scrapie cases [27,28], hence any animal with detectable PrPd in LRS only (35 cases in the present study) was likely to be missed as scrapie suspect.
Positive_regulation (accumulation) of LRS associated with congenital anomalies and scrapie
6) Confidence 0.02 Published 2010 Journal BMC Vet Res Section Body Doc Link PMC2875668 Disease Relevance 1.21 Pain Relevance 0

General Comments

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