INT1163

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Context Info
Confidence 0.29
First Reported 1975
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 64
Total Number 64
Disease Relevance 16.80
Pain Relevance 34.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
synapse 4
tail 3
spinal 2
cerebral cortex 2
neurons 2
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 613 100.00 Very High Very High Very High
antagonist 125 100.00 Very High Very High Very High
Glutamate receptor 125 100.00 Very High Very High Very High
nociceptor 74 100.00 Very High Very High Very High
Inflammation 60 100.00 Very High Very High Very High
opioid receptor 55 100.00 Very High Very High Very High
gABA 43 100.00 Very High Very High Very High
mu opioid receptor 39 100.00 Very High Very High Very High
Opioid 38 100.00 Very High Very High Very High
Dynorphin 17 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 58 100.00 Very High Very High Very High
Targeted Disruption 158 99.84 Very High Very High Very High
Inflammatory Pain 33 99.84 Very High Very High Very High
Neuropathic Pain 57 99.40 Very High Very High Very High
Hypersensitivity 11 99.30 Very High Very High Very High
Ganglion Cysts 214 99.26 Very High Very High Very High
Amnesia 3 99.20 Very High Very High Very High
Malaria 30 99.00 Very High Very High Very High
Nociception 159 98.96 Very High Very High Very High
Pain 102 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, beta-funaltrexamine (40 mg/kg, s.c.), which preferentially blocks mu(1)/mu(2) opioid receptors, naloxonazine (35 mg/kg, s.c.), a selective mu(1) opioid antagonist, naltrindole (10 mg/kg, s.c.), a selective delta opioid antagonist, and Nor-binaltorphimine (10 mg/kg, s.c.), which selectively blocks kappa-opioid receptors, were all ineffective.
Negative_regulation (blocks) of receptors associated with antagonist, kappa opioid receptor, opioid receptor and opioid
1) Confidence 0.29 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15157989 Disease Relevance 0.07 Pain Relevance 1.04
A possibility was considered that certain antidepressants selectively blocked the hypothalamic DA receptors, thereby antagonizing the hypothermic effects of apomorphine, leaving the extra-hypothalamic dopaminergic responses of this DA agonist unaffected.
Negative_regulation (blocked) of receptors associated with antidepressant and agonist
2) Confidence 0.29 Published 1984 Journal Neuropharmacology Section Abstract Doc Link 6325987 Disease Relevance 0.46 Pain Relevance 0.50
Both noncompetitively inhibit NMDA receptors, yet there is little evidence that these drugs affect GABA(A) receptors, the primary target of most anesthetics. alpha6beta2/3delta receptors are subtypes of the GABA(A) receptor family and are abundantly expressed in granular neurons within the adult cerebellum.
Negative_regulation (inhibit) of receptors in cerebellum associated with gaba and nmda receptor
3) Confidence 0.28 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18480294 Disease Relevance 0.28 Pain Relevance 0.59
These doses of opioid antagonists did not inhibit spinal mu receptors or kappa receptor agonist-induced analgesia as assessed by absence of effect on Tyr-D-Ala2-N-MePhe4-Gly-ol5 or U50,488H i.t. analgesia.
Negative_regulation (inhibit) of receptors in spinal associated with antagonist, agonist, opioid and analgesia
4) Confidence 0.27 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2574738 Disease Relevance 0 Pain Relevance 1.43
These behaviors are inhibited by L-PIA (N6-L-phenylisopropyl adenosine) and stimulated by caffeine, which suggest that a blockade of adenosine receptors is involved in these behaviors.
Negative_regulation (blockade) of receptors associated with adenocard
5) Confidence 0.21 Published 1989 Journal Yakubutsu Seishin Kodo Section Abstract Doc Link 2557712 Disease Relevance 0 Pain Relevance 0.78
In male mice the endogenous opioid systems did not seem to play a significant role in restraint-induced antinociception, whereas for female animals blockade of opioid delta receptors greatly diminished the antinociception observed after restraint.
Negative_regulation (blockade) of receptors associated with antinociception, endogenous opioid and opioid
6) Confidence 0.16 Published 1994 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 7934309 Disease Relevance 0 Pain Relevance 0.94
Simultaneously, the number of CCK-8, benzodiazepine and GABA-A receptors in cerebral cortex was decreased.
Negative_regulation (decreased) of receptors in cerebral cortex associated with gaba and cerebral cortex
7) Confidence 0.16 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2111914 Disease Relevance 0 Pain Relevance 0.70
Simultaneously, the number of CCK-8, benzodiazepine and GABA-A receptors in cerebral cortex was decreased.
Negative_regulation (number) of receptors in cerebral cortex associated with gaba and cerebral cortex
8) Confidence 0.16 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2111914 Disease Relevance 0 Pain Relevance 0.70
Blockade of kappa-opioid receptors by coadministration of nor-binaltorphimine or Win 44,441-3 with beta-endorphin given i.t. dose dependently inhibited i.t. beta-endorphin-induced inhibition of the tail-flick response.
Negative_regulation (Blockade) of receptors in tail associated with tail-flick and kappa opioid receptor
9) Confidence 0.13 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1316280 Disease Relevance 0 Pain Relevance 0.69
Blockade of alpha 2-adrenoceptors and 5-HT receptors by i.t. injection of yohimbine and methysergide, respectively, also did not affect inhibition of the tail-flick response induced by beta-endorphin given i.t.
Negative_regulation (Blockade) of receptors in tail associated with tail-flick
10) Confidence 0.13 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1316280 Disease Relevance 0 Pain Relevance 0.84
Furthermore, analgesic effect of [D.Ala2]deltorphin-I was antagonized by pretreatment with naltrexone but not by naltrindole, a selective antagonist of delta-opioid receptors.
Neg (not) Negative_regulation (antagonist) of receptors associated with antagonist, analgesic and delta opioid receptors
11) Confidence 0.13 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8247256 Disease Relevance 0 Pain Relevance 0.73
Desensitization of delta-opioid receptors in the spinal cord by intrathecal pretreatment with [Met]enkephalin (5 microg) for 60 min attenuated i.c.v. administered etorphine-induced tail-flick inhibition.
Negative_regulation (Desensitization) of receptors in tail associated with tail-flick, enkephalin, delta opioid receptors, immobilon, intrathecal and spinal cord
12) Confidence 0.12 Published 1997 Journal Neuroscience Section Abstract Doc Link 9284359 Disease Relevance 0.06 Pain Relevance 2.21
Agglutination of anesthetic-treated untransformed cells by low doses of concanavalin A is accompanied by redistribution of concanavalin A receptors on the cell surface to form patches, similar to that occurring in spontaneous agglutination of virus-transformed cells by concanavalin A.
Negative_regulation (redistribution) of receptors
13) Confidence 0.09 Published 1975 Journal Biochim. Biophys. Acta Section Abstract Doc Link 167839 Disease Relevance 0 Pain Relevance 0.30
In homozygous mice, a down-regulation of mu and delta receptors was observed in the striatal and pallidal areas.
Negative_regulation (down-regulation) of receptors
14) Confidence 0.09 Published 2008 Journal Neuroscience Section Abstract Doc Link 18424009 Disease Relevance 0.09 Pain Relevance 0.53
Pretraining administration of leu-enkephalin (0.2 mg/kg) facilitated the efficiency of the action of the blockade of benzodiazepine receptors on the retrieval of the passive avoidance response whereas the blockade of GABA-A receptors and chloride channels was non-effective.
Negative_regulation (blockade) of receptors associated with gaba and enkephalin
15) Confidence 0.08 Published 1994 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 8171909 Disease Relevance 0.17 Pain Relevance 0.50
A reduction in the number of Ca(2+)-permeable AMPA receptors and density of AMPA channel currents in spinal neurons of GluR-A-deficient mice is accompanied by a loss of nociceptive plasticity in vitro and a reduction in acute inflammatory hyperalgesia in vivo.
Negative_regulation (reduction) of receptors in spinal associated with nociception, hyperalgesia and inflammation
16) Confidence 0.08 Published 2004 Journal Neuron Section Abstract Doc Link 15541312 Disease Relevance 0.92 Pain Relevance 0.61
Because both the kappa and delta antagonists inhibited significantly the analgesic effect of morphine in beta-FNA-treated mice at doses that had no effect on morphine analgesia in control mice, these data suggest that morphine interacts with both kappa and delta receptors to produce analgesia when the population of functional mu receptors is drastically reduced by alkylation with beta-FNA.
Negative_regulation (reduced) of receptors associated with analgesic, antagonist, analgesia and morphine
17) Confidence 0.07 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2822908 Disease Relevance 0 Pain Relevance 1.47
The purpose of the present study was to determine if the highly mu-selective compound etonitazene could produce supraspinal (intracerebroventricular; i.c.v.) antinociception in CXBK mice, which are deficient in brain mu1, but not mu2, opioid receptors.
Negative_regulation (deficient) of receptors in brain associated with antinociception, opioid receptor and intracerebroventricular
18) Confidence 0.07 Published 1994 Journal Life Sci. Section Abstract Doc Link 7910928 Disease Relevance 0 Pain Relevance 1.07
By disrupting the genes encoding GluR-A or GluR-B, we generated mice exhibiting increased or decreased numbers of Ca(2+)-permeable AMPA receptors, respectively.
Negative_regulation (decreased) of receptors
19) Confidence 0.06 Published 2004 Journal Neuron Section Abstract Doc Link 15541312 Disease Relevance 0.74 Pain Relevance 0.50
The first series of experiments examined the thermal consequence of the absence of mu-opioid receptors on circadian body temperature rhythm and basal body temperature.
Negative_regulation (absence) of receptors in body associated with mu opioid receptor
20) Confidence 0.06 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17898318 Disease Relevance 0.52 Pain Relevance 0.36

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