INT116387

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.00
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Adm) aging (Adm) extracellular region (Adm)
response to stress (Adm) cytoplasm (Adm)
Anatomy Link Frequency
myocytes 1
epithelial cell 1
Adm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 2 96.12 Very High Very High Very High
sSRI 2 93.24 High High
fluoxetine 2 65.32 Quite High
metalloproteinase 302 63.96 Quite High
antagonist 2 54.68 Quite High
cytokine 46 54.16 Quite High
COX-2 inhibitor 1 50.56 Quite High
electroacupuncture 6 50.00 Quite Low
ischemia 4 44.60 Quite Low
Inflammation 47 26.48 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 80 100.00 Very High Very High Very High
Apoptosis 18 97.60 Very High Very High Very High
Increased Venous Pressure Under Development 1 84.52 Quite High
Sepsis 5 75.00 Quite High
Stress 18 66.32 Quite High
Sprains And Strains 8 64.16 Quite High
Cv General 4 Under Development 2 44.60 Quite Low
Death 3 43.52 Quite Low
Inflammatory Bowel Disease 2 27.04 Quite Low
Disease 8 17.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine.
adrenomedullin gene Binding (Association) of
1) Confidence 0.47 Published 2010 Journal Pharmacogenomics J. Section Title Doc Link 19636336 Disease Relevance 0 Pain Relevance 0.16
Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine.
ADM Binding (Association) of
2) Confidence 0.41 Published 2010 Journal Pharmacogenomics J. Section Title Doc Link 19636336 Disease Relevance 0 Pain Relevance 0.16
The results indicate that ADM interacts with COX to yield prostanoids, which mediate its negative inotropic effect in LPS-treated rat ventricular myocytes.
ADM Binding (interacts) of in myocytes
3) Confidence 0.37 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14766677 Disease Relevance 0.20 Pain Relevance 0.05
The activation of mitogen-activated protein kinase and the DNA binding activity of nuclear factor (NF)-kappaB and activator protein (AP)-1 were examined.
AP Spec (examined) Binding (activity) of
4) Confidence 0.35 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843806 Disease Relevance 0 Pain Relevance 0
This method measures the DNA-binding activity of activator protein (AP)-1 by ELISA.
AP Binding (activity) of
5) Confidence 0.35 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.03
This method measures the DNA-binding activity of activator protein (AP)-1 by ELISA.
AP Binding (binding) of
6) Confidence 0.35 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.03
In conclusion, the present study is to our knowledge the first to show that pre-treatment with multispecies probiotics, stimulates mucosal GSH biosynthesis and consequently normalizes AP-induced barrier dysfunction and attenuates epithelial cell apoptosis and disruption of TJs in a model of AP.
AP Binding (normalizes) of in epithelial cell associated with pancreatitis and apoptosis
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639703 Disease Relevance 0.80 Pain Relevance 0.03

General Comments

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