INT116459

From wiki-pain
Revision as of 18:23, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 5.66
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF)
proteinaceous extracellular matrix (VWF)
Anatomy Link Frequency
platelet 3
blood 1
plasma 1
blood vessels 1
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 19 98.48 Very High Very High Very High
cytokine 28 95.08 Very High Very High Very High
Bioavailability 1 86.00 High High
anesthesia 9 84.88 Quite High
antagonist 29 72.56 Quite High
Inflammation 81 70.04 Quite High
rheumatoid arthritis 13 60.68 Quite High
Arthritis 5 56.44 Quite High
abdominal pain 4 53.36 Quite High
anakinra 8 28.72 Quite Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 17 98.48 Very High Very High Very High
Adhesions 34 98.32 Very High Very High Very High
Neurological Disease 1 97.08 Very High Very High Very High
Fever 2 95.96 Very High Very High Very High
Acute Renal Failure 1 95.68 Very High Very High Very High
Thrombocytopenia 2 94.84 High High
Thrombotic Thrombocytopenic Purpura 8 94.24 High High
Hemolytic Anemia 1 94.12 High High
Pancreatitis 8 93.60 High High
Pressure Volume 2 Under Development 48 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The factor VIII-von Willebrand factor complex was documented in 84 patients, and plasma von Willebrand factor level was decreased (<60%) in 23 (27%) of them; 10 of the 84 patients (12%) had more notably decreased levels (<50%).
Negative_regulation (decreased) of von Willebrand factor in plasma
1) Confidence 0.58 Published 2008 Journal Arch Dermatol Section Body Doc Link 18645137 Disease Relevance 0 Pain Relevance 0
Along with ROS, VEGF, and a large number of mature and immature CD31/vWF positive blood vessels were present in the adhesion tissue.
Negative_regulation (number) of vWF in blood vessels associated with adhesions
2) Confidence 0.42 Published 2004 Journal World J Surg Section Abstract Doc Link 14961185 Disease Relevance 1.35 Pain Relevance 0.05
The pathophysiology has recently been elucidated by the discovery of a von Willebrand factor-cleaving protease (ADAMTS13) deficiency involved in platelet aggregation and ischemia.
Negative_regulation (deficiency) of von Willebrand factor in platelet associated with ischemia
3) Confidence 0.42 Published 2008 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 18989146 Disease Relevance 1.71 Pain Relevance 0.10
Factor VIII activity and von Willebrand factor level were significantly reduced in the HES 264/0.45 group compared with the albumin group after infusion of 15 mL/kg, 30 mL/kg, and 45 mL/kg (P < 0.05).
Negative_regulation (reduced) of von Willebrand factor
4) Confidence 0.25 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15920225 Disease Relevance 0 Pain Relevance 0.08
During NSTEMI, a rise in von Willebrand Factor (vWF) between 24 and 48 h predicts adverse clinical events [18], and an association between circulating levels of IL-6 and von Willebrand factor (vWF) has recently been shown to determine prognosis in patients with ACS [34].
Negative_regulation (rise) of vWF associated with acute coronary syndrome
5) Confidence 0.15 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.39 Pain Relevance 0.24
During NSTEMI, a rise in von Willebrand Factor (vWF) between 24 and 48 h predicts adverse clinical events [18], and an association between circulating levels of IL-6 and von Willebrand factor (vWF) has recently been shown to determine prognosis in patients with ACS [34].
Negative_regulation (rise) of von Willebrand Factor associated with acute coronary syndrome
6) Confidence 0.15 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.39 Pain Relevance 0.24
Decrease in whole blood viscosity and collagen-induced platelet aggregation, improvement in red blood cell deformability and reduction in Von Willebrand factor (vWf) concentration are some of the possible mechanisms (Szapary et al 2004).


Negative_regulation (reduction) of vWf in platelet
7) Confidence 0.11 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546474 Disease Relevance 0.59 Pain Relevance 0.17
Most of the results were in line with our study, however, the decreases of factor VIII and VWF after HES infusion were more pronounced than the decrease of the hematocrit.
Negative_regulation (decreases) of VWF
8) Confidence 0.10 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876854 Disease Relevance 0.18 Pain Relevance 0
Interestingly, after a first peak of adhesion, there is a rapid decrease in the number of adherent platelets, suggesting that the endothelial surface becomes less adhesive with time, possibly because vWF or other factors are progressively washed away [16].
Spec (possibly) Negative_regulation (washed) of vWF in platelets associated with adhesions
9) Confidence 0.09 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC117121 Disease Relevance 0.58 Pain Relevance 0
In this case, the proportional decrease of factor VIII and VWF 30 minutes after ANH was also beyond that expected from hemodilution alone and they fell below the normal range in the O group.
Negative_regulation (decrease) of VWF
10) Confidence 0.09 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2876854 Disease Relevance 0.14 Pain Relevance 0
Individuals with type O blood are more likely to have reduced factor VIII and von Willebrand factor levels compared to their non-O counterparts.
Negative_regulation (reduced) of von Willebrand factor in blood
11) Confidence 0.04 Published 2010 Journal Korean Journal of Anesthesiology Section Abstract Doc Link PMC2876854 Disease Relevance 0.33 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox