INT116553

Context Info Confidence 0.37 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.35 Pain Relevance 0.50

nucleus (Ikbkb) kinase activity (Ikbkb) cytoplasm (Ikbkb)

Ikbkb (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 11 93.76 Inflammation 31 79.84 Hyperalgesia 3 76.80 Eae 2 75.00 neuralgia 3 25.00 Pain 3 25.00 COX2 2 25.00 Analgesic 2 25.00 Spinal cord 1 25.00 Neuropathic pain 1 25.00

Disease Link Frequency Relevance Heat Stress 2 95.28 Injury 2 85.44 Infection 2 84.72 INFLAMMATION 28 79.84 Glioma 2 78.68 Hyperalgesia 3 76.80 Neuropathic Pain 3 75.00 Autoimmune Disease 12 66.00 Targeted Disruption 3 58.64 Opportunistic Infections 1 50.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IKK2 phosphorylates the Ser32 and Ser36 residues of I?

Phosphorylation (phosphorylates) of IKK2

1) Confidence 0.37 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.57 Pain Relevance 0.23

Because LPS is known to stimulate inhibitor kappaB (IkappaB) kinase (IKK)-mediated phosphorylation of IkappaB followed by its degradation, which in turn induces nuclear factor (NF)-kappaB nuclear translocation leading to transcriptional activation of COX-2 gene, the effect of gamma-mangostin on the IKK/IkappaB cascade controlling the NF-kappaB activation was examined.

Phosphorylation (phosphorylation) of inhibitor kappaB

2) Confidence 0.15 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.15 Pain Relevance 0

Phosphorylation of IkappaB through IkappaB kinase (IKK) is the first step in nuclear factor kappaB (NF-kappaB) activation and upregulation of NF-kappaB-responsive genes.

Phosphorylation (Phosphorylation) of IkappaB kinase

3) Confidence 0.15 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973242 Disease Relevance 0.63 Pain Relevance 0.26

General Comments

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