INT11658

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 3.09
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
chondrocytes 8
cartilage 2
extracellular matrix 2
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 5 99.84 Very High Very High Very High
cytokine 14 94.52 High High
cINOD 8 94.16 High High
Osteoarthritis 103 90.52 High High
Inflammation 24 86.80 High High
Potency 1 73.52 Quite High
backache 9 68.80 Quite High
metalloproteinase 19 59.36 Quite High
Arthritis 3 30.16 Quite Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Otitis Media 82 100.00 Very High Very High Very High
Hemophilus Infection 19 99.90 Very High Very High Very High
Aging 5 99.18 Very High Very High Very High
Stress 15 95.48 Very High Very High Very High
Hypertrophy 22 95.16 Very High Very High Very High
INFLAMMATION 33 93.84 High High
Osteoarthritis 123 90.52 High High
Intervertebral Disk Degeneration 78 89.76 High High
Disease 76 81.28 Quite High
Apoptosis 2 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then assessed the effect of the AAA hydrogel on NHC (Normal Human Chondrocyte) cell viability and on the production of important extracellular matrix factors, such as glycosaminoglycans and Type II collagen.
Regulation (effect) of Gene_expression (production) of Type II collagen in extracellular matrix
1) Confidence 0.62 Published 2008 Journal Journal of biomedical materials research. Part A Section Abstract Doc Link 17618483 Disease Relevance 0.16 Pain Relevance 0.07
It did not upregulate chondrocyte proliferation and type II collagen synthesis as evidenced by the lack of significant changes in the expression of cyclin B2 and COL2A1, respectively.
Regulation (changes) of Gene_expression (expression) of COL2A1 in chondrocyte
2) Confidence 0.59 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.51 Pain Relevance 0.17
As fibrocartilaginous collagen type I and hyaline collagen type II expression are differentially regulated in chondrocytes [34], analyzing the collagen type II/type I expression ratios is informative of chondrogenic potential [51].
Regulation (regulated) of Gene_expression (expression) of collagen type II in chondrocytes
3) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.29 Pain Relevance 0.08
Even at an etodolac concentration of 80 micrograms/ml, DNA synthesis, proteoglycan synthesis, and type-II collagen synthesis were unchanged.
Neg (unchanged) Regulation (unchanged) of Gene_expression (synthesis) of type-II collagen
4) Confidence 0.42 Published 1989 Journal Clin. Rheumatol. Section Abstract Doc Link 2545406 Disease Relevance 0.16 Pain Relevance 0.12
NTHi was responsible for 27/31 (87%) H. influenzae AOM episodes in this study.
Regulation (responsible) of Gene_expression (episodes) of AOM associated with hemophilus infection and otitis media
5) Confidence 0.32 Published 2011 Journal BMC Infect Dis Section Body Doc Link PMC3023699 Disease Relevance 0.88 Pain Relevance 0
Interestingly, while the SOX9 dependency of COL2A1 expression has been unequivocally shown, it may not actually be a key regulator of COL2A1 promoter activity in human adult articular chondrocytes [82].
Regulation (dependency) of Gene_expression (expression) of COL2A1 in chondrocytes
6) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.12 Pain Relevance 0
Proteoglycan production was also markedly decreased by ASA, while synthesis of type II collagen was not modified.
Neg (not) Regulation (modified) of Gene_expression (synthesis) of type II collagen associated with aspirin
7) Confidence 0.25 Published 1992 Journal Clin. Rheumatol. Section Abstract Doc Link 1582121 Disease Relevance 0.09 Pain Relevance 0.42
Gruber et al considered that loss of expression of Sox9 in some of the anulus cell population may play a role in disc aging and degeneration, possibly by decreased modulation of the expression and production of Type II collagen of disc cells 36.
Spec (possibly) Regulation (modulation) of Gene_expression (production) of Type II collagen associated with aging
8) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0
Gruber et al considered that loss of expression of Sox9 in some of the anulus cell population may play a role in disc aging and degeneration, possibly by decreased modulation of the expression and production of Type II collagen of disc cells 36.
Spec (possibly) Regulation (modulation) of Gene_expression (expression) of Type II collagen associated with aging
9) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0
Etodolac preserves cartilage-specific phenotype in human chondrocytes: effects on type II collagen synthesis and associated mRNA levels.
Regulation (effects) of Gene_expression (synthesis) of type II collagen in cartilage
10) Confidence 0.11 Published 1990 Journal Eur J Rheumatol Inflamm Section Title Doc Link 2146129 Disease Relevance 0.06 Pain Relevance 0.24
Under these experimental conditions 15d-PGJ2 displayed no cytotoxicity, as assessed by the conversion of a tetrazolium compound to its formazan product, as well as trypan blue exclusion (data not shown). 15d-PGJ2 inhibited type II collagen, a marker for differentiation of chondrocytes, and SOX-9 expression, a major transcription factor that regulates type II collagen expression, in a dose- and time-dependent manner as determined by immunoblot analysis (Fig. 1A).
Regulation (regulates) of Gene_expression (expression) of type II collagen in chondrocytes
11) Confidence 0.08 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693859 Disease Relevance 0 Pain Relevance 0

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