INT116605

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 16.88
Pain Relevance 8.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
oxidoreductase activity (Nos2) peroxisome (Nos2) nucleus (Nos2)
Anatomy Link Frequency
macrophages 3
phagocytes 2
PGE2 2
sciatic nerve 2
monocyte 1
Nos2 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 231 100.00 Very High Very High Very High
Pain 64 100.00 Very High Very High Very High
COX2 36 100.00 Very High Very High Very High
Inflammatory response 20 99.84 Very High Very High Very High
allodynia 132 99.74 Very High Very High Very High
Inflammation 318 99.20 Very High Very High Very High
cytokine 144 98.68 Very High Very High Very High
Spinal cord 176 97.72 Very High Very High Very High
Morphine 13 97.34 Very High Very High Very High
Hippocampus 26 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 396 100.00 Very High Very High Very High
INFLAMMATION 362 99.84 Very High Very High Very High
Neuropathic Pain 215 99.74 Very High Very High Very High
Pain 50 99.52 Very High Very High Very High
Apoptosis 32 99.40 Very High Very High Very High
Cancer 327 99.32 Very High Very High Very High
Adhesions 45 99.24 Very High Very High Very High
Sprains And Strains 282 98.08 Very High Very High Very High
Periodontal Pocket 3 98.00 Very High Very High Very High
Nociception 31 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structural and functional characterization of the iNOS promoter has identified binding elements for both EGFR and STAT3 (Lo et al. 2005).
iNOS Binding (binding) of
1) Confidence 0.37 Published 2007 Journal Transgenic Res Section Body Doc Link PMC1829418 Disease Relevance 0.67 Pain Relevance 0
Interaction of inducible nitric oxide synthase and cyclooxygenase-2 inhibitors in formalin-induced nociception in mice.
inducible nitric oxide synthase Binding (Interaction) of associated with nociception and cox2
2) Confidence 0.36 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15178354 Disease Relevance 0.10 Pain Relevance 0.47
However, limited information is available about the interaction between inducible NO synthase (iNOS) and COX inhibitors in pain perception.
inducible NO synthase Binding (interaction) of associated with pain
3) Confidence 0.36 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18292449 Disease Relevance 0.27 Pain Relevance 0.34
However, limited information is available about the interaction between inducible NO synthase (iNOS) and COX inhibitors in pain perception.
iNOS Binding (interaction) of associated with pain
4) Confidence 0.36 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18292449 Disease Relevance 0.27 Pain Relevance 0.34
Administration of SMT and targeted abrogation of iNOS gene blocked the enhancement of myocardial PGE2 and 6-keto-PGF(1alpha) 24 h after morphine administration but did not inhibit the up-regulation of COX-2 expression.
iNOS Binding (abrogation) of associated with morphine
5) Confidence 0.35 Published 2006 Journal Life Sci. Section Abstract Doc Link 16325209 Disease Relevance 0.13 Pain Relevance 0.59
Although it has been reported that iNOS-deficient mice exhibit enhanced leukocyte–endothelium interactions in endotoxaemia [38] and that iNOS activity plays a protective role in response to inflammation [39], the role of iNOS during acute peritonitis has not been addressed.
iNOS Binding (interactions) of in endothelium associated with inflammation and peritonitis
6) Confidence 0.35 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.73 Pain Relevance 0.16
Similarly, PGE2 down regulated the activity of inducible nitric oxide synthase (iNOS), which was up regulated by APAP.
inducible nitric oxide synthase Binding (activity) of in PGE2
7) Confidence 0.34 Published 2010 Journal Histol. Histopathol. Section Abstract Doc Link 20503171 Disease Relevance 0.25 Pain Relevance 0.18
Similarly, PGE2 down regulated the activity of inducible nitric oxide synthase (iNOS), which was up regulated by APAP.
iNOS Binding (activity) of in PGE2
8) Confidence 0.34 Published 2010 Journal Histol. Histopathol. Section Abstract Doc Link 20503171 Disease Relevance 0.25 Pain Relevance 0.18
The brown-yellow staining was recognized as positive staining for anti-NOS-2.
NOS-2 Binding (recognized) of
9) Confidence 0.34 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.47 Pain Relevance 0.40
In addition, our data also indicate that the presence of NOS2 is required for the increased expression of NOS1 in the spinal cord whereas an enhanced expression of NOS1 might avoid an up-regulation of NOS2 in the spinal cord of sciatic nerve-injured mice.
NOS2 Binding (presence) of in sciatic nerve associated with sciatic nerve and spinal cord
10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.43 Pain Relevance 1.01
NO production affects tumors that develop early suggesting an association of iNOS-induced NO with a more aggressive tumor phenotype, consistent with human clinical data positively correlating iNOS expression with breast cancer progression.
iNOS Binding (association) of associated with cancer and breast cancer
11) Confidence 0.32 Published 2007 Journal Transgenic Res Section Abstract Doc Link PMC1829418 Disease Relevance 1.40 Pain Relevance 0
CLP = cecal ligation and puncture; iNOS = inducible nitric oxide synthase; NIH = National Institutes of Health; NO = nitric oxide; WBC = white blood cell.


iNOS Binding (ligation) of in white blood cell
12) Confidence 0.31 Published 2007 Journal Crit Care Section Body Doc Link PMC2246221 Disease Relevance 0.82 Pain Relevance 0
B DNA binding (Supplemental Fig. 4B), two key transcriptional activators of iNOS.
iNOS Binding (binding) of
13) Confidence 0.31 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2803434 Disease Relevance 0.47 Pain Relevance 0.03
However, at variance with iNOS, this was not reflected by changes in the severity of inflammatory reaction to LPS.
iNOS Binding (variance) of associated with inflammation
14) Confidence 0.31 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 1.06 Pain Relevance 0.17
The experimental ED50 of the combination was significantly lower than the theoretical additive ED50 of the corresponding drug combination that substantiated the synergistic interaction between iNOS or NO and COX isoforms.
iNOS Binding (interaction) of
15) Confidence 0.30 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18292449 Disease Relevance 0.06 Pain Relevance 0
This hypothesis was supported by the absence of thermal allodynia observed in NOS2-KO mice at this time point after sciatic nerve ligation.
NOS2 Binding (ligation) of in sciatic nerve associated with targeted disruption, allodynia and sciatic nerve
16) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.53 Pain Relevance 1.03
For NOS2 although the two way ANOVA did not show any effect of the genotype or surgery, a significant interaction between theme was demonstrated (p<0.011).
NOS2 Binding (interaction) of
17) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 0.56 Pain Relevance 0.56
SB203580 treatment significantly reduced the immunoreactivity of iNOS, TNF-?
iNOS Binding (immunoreactivity) of
18) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.17 Pain Relevance 0.38
These data taken together led us to reinforce the hypothesis in the literature that the anti-inflammatory effect of propolis may be a due to inhibition of iNOS gene expression, through interference with NF-kappaB sites in the iNOS promoter.
iNOS Binding (interference) of associated with inflammation
19) Confidence 0.26 Published 2006 Journal Planta Med. Section Abstract Doc Link 16902858 Disease Relevance 0.43 Pain Relevance 0.38
COX-2 and iNOS), and it counteracts the release of pro-inflammatory cytokines, such as TNF-?
iNOS Binding (counteracts) of associated with inflammation and cytokine
20) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.77 Pain Relevance 0.44

General Comments

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