INT116614

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 11.39
Pain Relevance 4.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1)
cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)
Anatomy Link Frequency
brain 4
neurons 2
spinal cord 2
NSCs 2
hippocampus 2
Bcl2l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 2 99.92 Very High Very High Very High
Nerve growth factor 3 99.84 Very High Very High Very High
Hippocampus 6 99.68 Very High Very High Very High
Spinal cord 9 98.58 Very High Very High Very High
ischemia 99 98.32 Very High Very High Very High
amygdala 5 97.96 Very High Very High Very High
fluoxetine 13 97.80 Very High Very High Very High
Abeta 3 96.88 Very High Very High Very High
dexamethasone 43 96.80 Very High Very High Very High
Sciatic nerve 2 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 192 100.00 Very High Very High Very High
Injury 43 100.00 Very High Very High Very High
Shock 1 100.00 Very High Very High Very High
Optic Neuritis 2 99.92 Very High Very High Very High
Convulsion 4 99.74 Very High Very High Very High
Middle Cerebral Artery Infarction 14 99.36 Very High Very High Very High
Retina Disease 17 98.32 Very High Very High Very High
Stroke 106 97.16 Very High Very High Very High
INFLAMMATION 61 94.88 High High
Frailty 4 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An early (2-3 days post-CCI) E2F1- and p53-independent apoptosis appeared in the spinal cord as the pro-apoptotic bax gene increased (320 +/- 19%), followed by an increased expression of the anti-apoptotic bcl-2 and bcl-xL genes (60 +/- 11% and 110 +/- 15%, respectively) 7 days from CCI.
Positive_regulation (increased) of Gene_expression (expression) of bcl-xL in spinal cord associated with injury, apoptosis and spinal cord
1) Confidence 0.67 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975670 Disease Relevance 1.78 Pain Relevance 0.85
Transduction of Bcl-XL in our study led to significant rescue of RGCs indicating the relevance of this pathway for neuronal survival under autoimmune inflammatory conditions.
Positive_regulation (Transduction) of Gene_expression (Transduction) of Bcl-XL in RGCs associated with inflammation
2) Confidence 0.49 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 16242630 Disease Relevance 1.22 Pain Relevance 0.33
Active caspase-3 and Bax expressions were increased, whereas antiapoptotic Bcl-xl and heat shock protein (HSP) 27 expressions in DRGs were increased.
Positive_regulation (increased) of Gene_expression (expressions) of Bcl-xl associated with shock
3) Confidence 0.49 Published 2005 Journal Diabetes Section Abstract Doc Link 16249457 Disease Relevance 1.39 Pain Relevance 0.61
The up-regulated expression of Bcl-2, Bcl-xL and the cellular FLICE-inhibitory protein (c-FLIP) in fluoxetine-treated NSCs was detected by real-time RT-PCR.
Positive_regulation (up-regulated) of Gene_expression (expression) of Bcl-xL in NSCs associated with fluoxetine
4) Confidence 0.45 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16545775 Disease Relevance 0.25 Pain Relevance 0.96
Reboxetine, tranylcypromine, and ECS selectively increased Bcl-xl, but not Bcl-2 mRNA expression in the hippocampus.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of Bcl-xl in hippocampus associated with convulsion and hippocampus
5) Confidence 0.44 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17700647 Disease Relevance 1.04 Pain Relevance 0.67
In addition, mefenamic acid up-regulates expression of the antiapoptotic protein Bcl-X(L).
Positive_regulation (regulates) of Gene_expression (expression) of Bcl-X
6) Confidence 0.38 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16223958 Disease Relevance 0.90 Pain Relevance 0.54
Taken together, we concluded that magnolol inhibits apoptosis through enhancing the activation of ERK1/2 and modulation of the Bcl-xl proteins which brings about reduction of infarct size and improvement of cardiac function in I/R-induced injury.
Positive_regulation (activation) of Gene_expression (modulation) of Bcl-xl associated with injury and apoptosis
7) Confidence 0.37 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18641058 Disease Relevance 0.65 Pain Relevance 0.04
Taken together, we concluded that magnolol inhibits apoptosis through enhancing the activation of ERK1/2 and modulation of the Bcl-xl proteins which brings about reduction of infarct size and improvement of cardiac function in I/R-induced injury.
Positive_regulation (enhancing) of Gene_expression (modulation) of Bcl-xl associated with injury and apoptosis
8) Confidence 0.37 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18641058 Disease Relevance 0.66 Pain Relevance 0.04
It clearly finds an association with an increase in Bax with a decrease in Bcl-xL expression and negates any involvement of Bak and Bcl-2 regulations in the damage induced by retinal ischemia 24 h after reperfusion.
Positive_regulation (increase) of Gene_expression (expression) of Bcl-xL associated with ischemia and retina disease
9) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.72 Pain Relevance 0.18
As seen in figure 7, immunofluorescent staining performed in brain sections from animals after 24 hr of reperfusion showed that, in comparable regions, H-100-treated brain expressed higher levels of Bcl-xL than vehicle-treated brain.
Positive_regulation (levels) of Gene_expression (expressed) of Bcl-xL in brain
10) Confidence 0.16 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.38 Pain Relevance 0
We further performed TUNEL staining of brain tissue to see if higher Bcl-xL expression in the treated group translated to an anti-apoptotic effect.
Positive_regulation (higher) of Gene_expression (expression) of Bcl-xL in brain associated with apoptosis
11) Confidence 0.16 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.40 Pain Relevance 0
The expression of Bcl-XL was increased approximately sevenfold within 24?
Positive_regulation (increased) of Gene_expression (expression) of Bcl-XL
12) Confidence 0.12 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.44 Pain Relevance 0.32
Administering melatonin prior to MCAO or at the onset of reperfusion restores the injury-induced reduction in phosphorylated AKT (p-AKT), p-Bad and Bcl-XL levels and the binding of p-Bad and 14-3-3 as well as decreases caspase-3 activation.38,39 Treatment of melatonin also suppresses the immunoreactivity of cytosolic cytochrome c oxdiase in the ischemic cortex four and 24 hours after MCAO.40 To investigate whether melatonin directly inhibits neuronal apoptosis after hypoxia/ischemia, mouse striatal neurons are cultured and subjected to oxygen and glucose deprivation (OGD).
Positive_regulation (restores) of Gene_expression (levels) of Bcl-XL in neurons associated with hypoxia, middle cerebral artery infarction, ischemia, injury and neurodegenerative disease
13) Confidence 0.07 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695239 Disease Relevance 1.57 Pain Relevance 0.16

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