INT116707

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Context Info
Confidence 0.21
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 13
Disease Relevance 9.83
Pain Relevance 7.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapk4) cell cycle (Mapk4) cytoplasm (Mapk4)
Anatomy Link Frequency
microglia 3
brain 2
dorsal horn 2
caudal regions 2
spinal cord 1
Mapk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 25 99.84 Very High Very High Very High
allodynia 21 99.12 Very High Very High Very High
hyperexcitability 8 99.00 Very High Very High Very High
Hippocampus 110 98.88 Very High Very High Very High
Dorsal horn 5 98.82 Very High Very High Very High
Spontaneous pain 2 98.82 Very High Very High Very High
cytokine 2 98.68 Very High Very High Very High
Brush evoked pain 21 98.40 Very High Very High Very High
Visceral pain 10 96.92 Very High Very High Very High
ischemia 5 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 335 100.00 Very High Very High Very High
Cancer 3 99.48 Very High Very High Very High
Neuropathic Pain 46 99.12 Very High Very High Very High
Pain 21 98.82 Very High Very High Very High
Injury 4 98.30 Very High Very High Very High
Shock 10 98.04 Very High Very High Very High
Nervous System Injury 17 97.32 Very High Very High Very High
Frailty 4 97.08 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

10 96.92 Very High Very High Very High
Cv Unclassified Under Development 5 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury.
Positive_regulation (Activation) of p-38alpha MAPK in caudal regions associated with hyperexcitability and spinal cord
1) Confidence 0.21 Published 2009 Journal Exp. Neurol. Section Title Doc Link 19699199 Disease Relevance 0.43 Pain Relevance 0.66
Taken together, our results demonstrate that activation of P2X(4) or p38MAPK in spinal cord microglia is necessary for tactile allodynia after nerve injury.
Positive_regulation (activation) of p38MAPK in microglia associated with brush evoked pain, nervous system injury and spinal cord
2) Confidence 0.17 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 1.03 Pain Relevance 1.01
In the rats, activated microglia were detected in the injured side of the dorsal horn and the level of the dually-phosphorylated active form of p38MAPK (phospho-p38MAPK) in these microglia was increased.
Positive_regulation (increased) of p38MAPK in microglia associated with dorsal horn
3) Confidence 0.17 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 0.92 Pain Relevance 1.06
In the rats, activated microglia were detected in the injured side of the dorsal horn and the level of the dually-phosphorylated active form of p38MAPK (phospho-p38MAPK) in these microglia was increased.
Positive_regulation (increased) of p38MAPK in microglia associated with dorsal horn
4) Confidence 0.15 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 0.92 Pain Relevance 1.05
In the present study, we examined whether activation of p-38alpha MAPK modulates mechanical allodynia and neuronal hyperexcitability, and if propentofylline (PPF, a glial modulator) modulates specifically localized activated p-38alpha MAPK expression in caudal regions remote from a low thoracic hemisection injury in rats.
Spec (whether) Positive_regulation (activation) of p-38alpha MAPK in caudal regions associated with allodynia, injury and hyperexcitability
5) Confidence 0.14 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19699199 Disease Relevance 0.40 Pain Relevance 0.52
We have demonstrated that tactile allodynia and spontaneous pain of female rats with tibia tumors were correlated with the increase of both phosphorylated-p38MAPK (p-p38MAPK) and proinflammatory cytokines (IL-1beta and TNF-alpha) in the spinal cord 6 days after Walker 256 cells' inoculation.
Positive_regulation (increase) of p38MAPK in spinal cord associated with pain, brush evoked pain, cancer, spontaneous pain, spinal cord and cytokine
6) Confidence 0.08 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.08 Pain Relevance 0.92
In the rats, activated microglia were detected in the injury side of the dorsal horn where the level of the dually phosphorylated active form of p38MAPK (phospho-p38MAPK) was increased.
Positive_regulation (increased) of p38MAPK in dorsal horn associated with injury and dorsal horn
7) Confidence 0.07 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.18 Pain Relevance 0.98
In the rats, activated microglia were detected in the injury side of the dorsal horn where the level of the dually phosphorylated active form of p38MAPK (phospho-p38MAPK) was increased.
Positive_regulation (increased) of p38MAPK in dorsal horn associated with injury and dorsal horn
8) Confidence 0.07 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.18 Pain Relevance 0.97
(Although in the experiment shown in Figs. 5 and 6, there was a very modest increase in P-p38MAPK that was restricted to the hippocampus, there was no significant change in this phosphoprotein in an independent replication of this experiment; data not shown).
Positive_regulation (increase) of p38MAPK in hippocampus associated with hippocampus
9) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.36 Pain Relevance 0.08
We recently demonstrated that restraint stress activates the Erk MAPK pathway, but not c-Jun-N-terminal kinase/stress-activated protein kinase (JNK/SAPK) or p38MAPK, in several rat brain regions.
Positive_regulation (activates) of p38MAPK in brain associated with stress
10) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC526203 Disease Relevance 0.62 Pain Relevance 0.23
Since the major activators of p38MAPK are the closely related, dual specificity kinases phosphorylated MKK3 and MKK6 [39], we attempted to determine if swim stress increased the phosphorylation of this upstream kinase.
Positive_regulation (activators) of p38MAPK associated with stress
11) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.58 Pain Relevance 0.12
Effects of swim stress on activation of the p38MAPK pathway and phosphorylation of CREB
Positive_regulation (activation) of p38MAPK associated with stress
12) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.46 Pain Relevance 0.12
P-JNK levels (P-JNK1 and/or P-JNK2/3) were increased in all brain regions about 2–5-fold, whereas P-p38MAPK levels remained essentially unchanged.
Neg (unchanged) Positive_regulation (unchanged) of p38MAPK in brain
13) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC526203 Disease Relevance 0.52 Pain Relevance 0.25

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