INT116738

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 18
Disease Relevance 10.99
Pain Relevance 3.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
aging (Mif) extracellular region (Mif) nucleus (Mif)
Anatomy Link Frequency
bladder 14
spinal cord dorsal horn 4
lumen 2
lung 2
urine 2
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 298 99.20 Very High Very High Very High
Spinal cord 5 99.04 Very High Very High Very High
Inflammatory stimuli 30 98.66 Very High Very High Very High
Dorsal horn 2 98.56 Very High Very High Very High
dorsal root ganglion 23 97.72 Very High Very High Very High
cytokine 59 95.72 Very High Very High Very High
IPN 4 90.52 High High
cva 5 90.40 High High
Arthritis 10 90.08 High High
lidocaine 45 89.84 High High
Disease Link Frequency Relevance Heat
Overactive Bladder 10 99.88 Very High Very High Very High
Injury 63 99.44 Very High Very High Very High
INFLAMMATION 320 99.20 Very High Very High Very High
Adult Respiratory Distress Syndrome 7 99.12 Very High Very High Very High
Cystitis 105 98.52 Very High Very High Very High
Ganglion Cysts 42 97.72 Very High Very High Very High
Hyperplasia 10 97.36 Very High Very High Very High
Ocular Hypertension 282 97.12 Very High Very High Very High
Urinary Tract Infection 5 93.96 High High
Nociception 4 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further examination showed that levels of both MIF and the MIF receptor CD74 were substantially increased within the ipsilateral spinal cord dorsal horn after formalin administration.
Positive_regulation (increased) of Gene_expression (levels) of MIF receptor CD74 in spinal cord dorsal horn associated with dorsal horn and spinal cord
1) Confidence 0.68 Published 2010 Journal Pain Section Abstract Doc Link 20005040 Disease Relevance 0.57 Pain Relevance 0.61
Therefore, release of urothelial preformed MIF and activation of MIF production in the bladder (and urothelium in particular) by inflammatory stimuli are key elements in MIF-mediated bladder inflammation.
Positive_regulation (activation) of Gene_expression (production) of MIF in bladder associated with inflammation and inflammatory stimuli
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.77 Pain Relevance 0.45
We conclude that significant increases in bladder MIF expression and protein in response to intravesical LPS may represent part of this organ's initial innate immune response.
Positive_regulation (increases) of Gene_expression (expression) of MIF in bladder
3) Confidence 0.61 Published 2004 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 14980085 Disease Relevance 0.59 Pain Relevance 0.45
Further examination showed that levels of both MIF and the MIF receptor CD74 were substantially increased within the ipsilateral spinal cord dorsal horn after formalin administration.
Positive_regulation (increased) of Gene_expression (levels) of MIF in spinal cord dorsal horn associated with dorsal horn and spinal cord
4) Confidence 0.49 Published 2010 Journal Pain Section Abstract Doc Link 20005040 Disease Relevance 0.57 Pain Relevance 0.61
Cyclophosphamide upregulated bladder CXCR4 expression: MIF-CXCR4 associations in the bladder
Positive_regulation (upregulated) of Gene_expression (expression) of MIF in bladder
5) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Although SP and capsaicin increased the total amount of MIF detected by enzyme-linked immunosorbent assay in ILF, the patterns of MIF complexes elicited by these 2 treatments were different.
Positive_regulation (increased) of Gene_expression (detected) of MIF
6) Confidence 0.47 Published 2005 Journal J. Urol. Section Body Doc Link 15947686 Disease Relevance 0 Pain Relevance 0
Our recent experimental evidence indicates that MIF participates in bladder inflammation since: (1) MIF is constitutively expressed in the urothelium [4], [5]; (2) bladder MIF expression is upregulated in different models of experimental cystitis in animals [6], [7]; (3) MIF is released from the bladder during experimental cystitis [6], [8], [9] and urinary tract infections in humans [10] and finally, (4) neutralizing MIF with intravesical antibodies decreased experimental bladder inflammation [7].
Positive_regulation (upregulated) of Gene_expression (expression) of MIF in bladder associated with inflammation, cystitis and urinary tract infection
7) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.85 Pain Relevance 0.61
Thrombin induced upregulation of MIF expression in rat bladder tissue was determined by real time PCR.
Positive_regulation (upregulation) of Gene_expression (expression) of MIF in bladder
8) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
MIF ELISA was also tested for its ability to detect serum MIF.
Positive_regulation (tested) of Gene_expression (detect) of serum MIF
9) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
Frozen (coronal) bladder sections (12 µm) of mid-detrusor were exposed simultaneously to both MIF (1?
Positive_regulation (simultaneously) of Gene_expression (exposed) of MIF in bladder associated with overactive bladder
10) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.15 Pain Relevance 0
Compared to saline treatment, CYP treatment increased urinary MIF levels (as measured by ELISA; Figure 1E; 22.2±2.8 vs. 57.3±20.5 in saline vs CYP, respectively; p<0.0464) while decreasing bladder MIF levels (Fig 1F; 244.1±39.7 vs 136.0±38.1 ng MIF/mg protein in saline vs CYP treatment respectively; p?
Positive_regulation (urinary) of Gene_expression (levels) of MIF in bladder
11) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.56 Pain Relevance 0.12
Inflammatory stimuli elicit MIF release from the urothelium into the bladder lumen and upregulation of MIF expression by the bladder in general and urothelium in particular [8], [9].
Positive_regulation (upregulation) of Gene_expression (expression) of MIF in lumen associated with inflammatory stimuli
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.62 Pain Relevance 0.37
Thrombin induced upregulation of MIF expression in UROtsa cells was determined by real-time PCR (Opticon, BioRad).
Positive_regulation (upregulation) of Gene_expression (expression) of MIF
13) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0.08
Activation of urothelial PAR1 receptors, either by locally generated thrombin or proteases present in the urine, may mediate bladder inflammation by inducing urothelial MIF release and upregulating urothelial MIF expression.



Positive_regulation (upregulating) of Gene_expression (expression) of MIF in urine associated with inflammation
14) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013117 Disease Relevance 0.10 Pain Relevance 0.28
MIF gene expression and protein levels were significantly increased in murine and canine acute lung injury models.
Positive_regulation (increased) of Gene_expression (expression) of MIF in lung associated with adult respiratory distress syndrome
15) Confidence 0.31 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 1.64 Pain Relevance 0.21
Neuroprotection from Wolfberry extract-LBP on RGCs was not sustained after intravitreous injection of MIF when compared with the intravitreous injection of PBS (#p?
Positive_regulation (on) of Gene_expression (injection) of MIF
16) Confidence 0.26 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.19 Pain Relevance 0
Neuroprotection from Wolfberry extract-LBP on RGCs was not sustained after intravitreous injection of MIF when compared with the intravitreous injection of PBS (#p?
Positive_regulation (-) of Gene_expression (injection) of MIF
17) Confidence 0.26 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.19 Pain Relevance 0
Neuroprotection from Wolfberry extract-LBP on RGCs was not sustained after intravitreous injection of MIF when compared with the intravitreous injection of PBS (#p?
Neg (not) Positive_regulation (sustained) of Gene_expression (injection) of MIF
18) Confidence 0.26 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.18 Pain Relevance 0

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