INT116883

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 5.83
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SSX1) intracellular (SSX1)
Anatomy Link Frequency
joint 1
testis 1
SCP 1
SSX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 100.00 Very High Very High Very High
rheumatoid arthritis 96 98.50 Very High Very High Very High
Chronic pancreatitis 11 97.20 Very High Very High Very High
Osteoarthritis 48 75.12 Quite High
cytokine 14 25.00 Low Low
fibrosis 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Testicular Cancer 27 100.00 Very High Very High Very High
INFLAMMATION 24 100.00 Very High Very High Very High
Pancreatic Cancer 15 99.90 Very High Very High Very High
Arthropathy 2 99.64 Very High Very High Very High
Rheumatoid Arthritis 96 98.50 Very High Very High Very High
Cancer 12 98.04 Very High Very High Very High
Disease 14 97.60 Very High Very High Very High
Pancreatitis 11 97.20 Very High Very High Very High
Adenocarcinoma 4 94.84 High High
Immunotherapy Of Cancer 1 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we investigated the IgG antibody response against 11 cancer testis antigens (SCP-1, GAGE, LAGE-1a,-1b, CT-7, NY-ESO-1, SSX-1-5) recombinantly expressed on yeast surface (RAYS) in patients with pancreatic cancer (n = 96), chronic pancreatitis (n = 18) and healthy donors (n = 48).
Gene_expression (expressed) of SSX-1 in testis associated with pancreatic cancer, testicular cancer and chronic pancreatitis
1) Confidence 0.58 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16432832 Disease Relevance 1.40 Pain Relevance 0.10
While all CT genes were frequently expressed in cell lines derived from pancreatic cancer, no expression of MAGE-3, SSX-1, SSX-2, NY-ESO-1 and CT-7 was detected in fresh tumor biopsies, and MAGE-4 (1/52), SSX-4 (1/39) and CT-8 (2/41) were only rarely expressed.
Gene_expression (expression) of SSX-1 associated with cancer, pancreatic cancer and testicular cancer
2) Confidence 0.44 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.77 Pain Relevance 0.28
In order to define antigens that might be suitable as vaccines for pancreatic carcinoma, we investigated the composite expression of 10 cancer testis (CT) antigens (SCP-1, NY-ESO-1, SSX-1, SSX-2, SSX-4, GAGE, MAGE-3, MAGE-4, CT-7 and CT-8) by Reverse Transcriptase-PCR (RT-PCR) in fresh biopsies of human pancreatic adenocarcinoma, chronic pancreatitis and pancreatic carcinoma cell lines.
Spec (investigated) Gene_expression (expression) of SSX-1 in SCP associated with adenocarcinoma, pancreatic cancer, testicular cancer and chronic pancreatitis
3) Confidence 0.44 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.50 Pain Relevance 0.17
Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease characterized by overexpression of pro-inflammatory/pro-destructive genes and other activating genes (for example, proto-oncogenes) in the synovial membrane (SM).
Gene_expression (overexpression) of synovial membrane in joint associated with inflammation, rheumatoid arthritis and arthropathy
4) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575612 Disease Relevance 1.16 Pain Relevance 0.44

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