INT116900

Context Info Confidence 0.49 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 4.00 Pain Relevance 1.39

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1) plasma membrane (PRF1)

Anatomy Link Frequency T cells 3 PRF1 (Homo sapiens)

Pain Link Frequency Relevance Heat spinal inflammation 92 99.28 chemokine 48 87.00 drug abuse 1 79.12 depression 1 78.44 headache 1 72.96 Pain 2 70.56 cytokine 16 67.12 Inflammation 19 67.08 addiction 2 66.96 Inflammatory response 5 65.76

Disease Link Frequency Relevance Heat Cerebral Malaria 39 99.88 Low Back Pain 104 99.28 Malaria 48 98.64 Chronic Fatigue Syndrome 78 95.28 Epstein-barr Virus 32 92.72 Cytomegalovirus Infection 42 92.00 Disease 38 90.84 Infection 53 88.68 Sprains And Strains 3 82.08 Appetite Loss 1 81.12

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Other more recent studies, using malaria animal models, showed that experimental cerebral malaria (ECM) was induced in perforin-deficient mice (PFP-/-) after adoptive transfer of cytotoxic CD8+ T cells from infected C57BL/6 mice, which were directed to the brains of PFP-/-mice.

Positive_regulation (induced) of perforin in T cells associated with malaria and cerebral malaria

1) Confidence 0.49 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.24 Pain Relevance 0.32

Some studies have suggested that these decreases in NK function may involve low levels of granzymes, perforin proteins and increases in the expression of the granzyme gene GZMA [6,8].

Positive_regulation (increases) of perforin

2) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 1.47 Pain Relevance 0.26

For functional characterization of CD8+ CD28- T cells in AS patients, flow cytometric single cell analysis was used, and the intracellular accumulation of perforin and IFN-?

Positive_regulation (accumulation) of perforin in T cells associated with spinal inflammation

3) Confidence 0.08 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.70 Pain Relevance 0.53

The Mann–Whitney test was used to compare the percentages of CD8+CD28- T cells between AS patients and healthy controls, the percentages of perforin or IFN-?

Positive_regulation (percentages) of perforin in T cells associated with spinal inflammation

4) Confidence 0.07 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.50 Pain Relevance 0.29

CD4+CD28null cells were separated by flow cytometry and assessed for antigen recognition using upregulation of interferon-gamma and perforin mRNA transcription as criteria for activation.

Positive_regulation (upregulation) of perforin mRNA

5) Confidence 0.00 Published 2004 Journal Circulation Section Body Doc Link 14993140 Disease Relevance 0.08 Pain Relevance 0

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