INT116950

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 103
Total Number 104
Disease Relevance 44.48
Pain Relevance 17.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
Anatomy Link Frequency
fibroblasts 5
pericytes 1
MCF-7 1
cleavage 1
joint 1
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 8 100.00 Very High Very High Very High
Kinase C 49 99.92 Very High Very High Very High
neuralgia 6 99.80 Very High Very High Very High
aspirin 29 99.76 Very High Very High Very High
Nicotine 480 99.40 Very High Very High Very High
antagonist 108 99.34 Very High Very High Very High
allodynia 13 99.24 Very High Very High Very High
Leflunomide 46 99.20 Very High Very High Very High
Inflammatory stimuli 36 98.86 Very High Very High Very High
Spinal nerve ligature 20 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 541 100.00 Very High Very High Very High
Metastasis 157 99.92 Very High Very High Very High
Toxicity 30 99.82 Very High Very High Very High
Breast Cancer 194 99.76 Very High Very High Very High
Apoptosis 1267 99.40 Very High Very High Very High
Disease 1093 99.32 Very High Very High Very High
Neuropathic Pain 34 99.24 Very High Very High Very High
Carcinoma 96 99.14 Very High Very High Very High
Shock 48 99.12 Very High Very High Very High
Colon Cancer 23 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, a p38 MAPK and a JNK1/2 inhibitor were also used but failed to inhibit SHP mRNA induction by TCA (data not shown).
Negative_regulation (inhibitor) of JNK1
1) Confidence 0.57 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.06 Pain Relevance 0.03
Selective inhibitors of ERK, p38 MAPK, and JNK suppressed the induction of GRP78, CHOP, and PPAR-beta, attenuated indomethacin-induced cytotoxicity and reduced increased caspase activity.
Negative_regulation (inhibitors) of JNK
2) Confidence 0.45 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.85 Pain Relevance 0.11
In addition, significant upregulation of VEGF-C mRNA (Figure 7B) and a decreased level of phosphorylated JNK (Figure 7C) were also induced in H157 cells treated with siRNA-podoplanin.
Negative_regulation (decreased) of JNK
3) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.17 Pain Relevance 0
As a result, significant upregulation of VEGF-C mRNA (Figure 6C) and a decreased level of phosphorylated JNK (Figure 6D) were induced in EBC1-P4 cells treated with siRNA-podoplanin.
Negative_regulation (decreased) of JNK
4) Confidence 0.42 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.07 Pain Relevance 0
This correlated with inhibition of the downstream target of MEKK1 activity, i.e. the SAPK/JNK kinase.
Negative_regulation (inhibition) of JNK
5) Confidence 0.42 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2071920 Disease Relevance 0.05 Pain Relevance 0
Another set of experiments, developed to test the hypothesis that Akt kinase confers resistance to endocrine therapy through suppression of ASK1/JNK pathway, showed that combining RAD001 with letrozole restored activation of the ASK/JNK pathway and increased the sensitivity of MCF-7 cells with constitutively active Akt to endocrine therapy [48].
Negative_regulation (suppression) of JNK in MCF-7
6) Confidence 0.41 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.20 Pain Relevance 0
Consistently, pretreatment with JNK inhibitor SP600125 also decreased JNK activation (Fig. 5B, lane 4).
Negative_regulation (inhibitor) of JNK
7) Confidence 0.39 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.20 Pain Relevance 0
Furthermore, silencing of JNK expression by siJNKs (24), which efficiently reduced the endogenous JNK protein level (Fig. 5E) but not the control siRNA, decreased H2O2-induced AICD level (Fig. 5E, compare lanes 4 and 6 to lane 2).
Neg (not) Negative_regulation (reduced) of JNK
8) Confidence 0.39 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.10 Pain Relevance 0
Therefore, we hypothesized that leflunomide may protect from drugs that induce the mitochondrial permeability transition (mPT) by blocking the JNK signaling pathway.
Negative_regulation (blocking) of JNK associated with leflunomide
9) Confidence 0.39 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16979204 Disease Relevance 0.65 Pain Relevance 0.70
In the absence of JNK inhibition, the response of normal control fibroblasts after oxidative stress amounted to at most 30% apoptotic nuclei at both 250 µM (Figure 16A) and 500 µM (Figure 14) H2O2 by 10 hr after oxidative stress.
Negative_regulation (inhibition) of JNK in fibroblasts associated with stress and apoptosis
10) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.70 Pain Relevance 0
Blockade of JNK did not significantly enhance apoptosis in normal control fibroblasts that were not subjected to oxidative stress, confirming the specificity of the JNK effect for the stress state.
Negative_regulation (Blockade) of JNK in fibroblasts associated with stress and apoptosis
11) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.45 Pain Relevance 0
Overexpression of Galphat in COS-7 cells clearly suppressed kappa-opioid receptor-stimulated JNK activity, indicating that the pathway is primarily regulated by Gbetagamma.
Negative_regulation (suppressed) of JNK associated with kappa opioid receptor
12) Confidence 0.34 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14996948 Disease Relevance 0.13 Pain Relevance 0.44
Only the dual inhibitor of p38 and JNK and the use of combined siRNA silencing of p38 and cJun abrogated the ability of NO-aspirin to block cell growth.
Negative_regulation (inhibitor) of JNK associated with aspirin
13) Confidence 0.33 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16169935 Disease Relevance 0.47 Pain Relevance 0.41
Furthermore, Trolox attenuated indomethacin-induced increased phosphorylation in ERK, p38 MAPK, JNK, and AKT.
Negative_regulation (attenuated) of JNK
14) Confidence 0.32 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.61 Pain Relevance 0.05
Moreover, the podoplanin-mediated downregulation of the VEGF-C gene via JNK (the podoplanin-JNK-VEGF-C axis) was newly found as one of the possible underlying mechanisms.
Negative_regulation (downregulation) of JNK
15) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 1.18 Pain Relevance 0
A decreased level of phosphorylated JNK but not of total JNK was induced by siRNA-mediated podoplanin knockdown (Figures 6D and 7C), suggesting that podoplanin could induce JNK phosphorylation.
Negative_regulation (decreased) of JNK
16) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.27 Pain Relevance 0.04
Real-time RT-PCR revealed that the VEGF-C gene expression level in EBC1-Ps treated with sp600125, a JNK inhibitor, was significantly improved, nearly to the level found in EBC1-Vs (Figure 6A), whereas no change in the VEGF-C expression was observed in EBC1-Ps treated with the ROCK inhibitor Y-27632 (data not shown).
Negative_regulation (inhibitor) of JNK
17) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.17 Pain Relevance 0
The body of our findings is that podoplanin in LSCCs can induce VEGF-C downregulation via the JNK signaling pathway(s), and can impair tumor-associated lymphangiogenesis and lymphogenous metastasis
Negative_regulation (downregulation) of JNK in body associated with cancer and metastasis
18) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.81 Pain Relevance 0
Using either parental NCTC2544 or vector expressing cells (not shown) we found no equivalent inhibition of JNK activity (Panel A) at any concentration of peptide tested.
Negative_regulation (inhibition) of JNK
19) Confidence 0.30 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.08
have not revealed a specific isoform to date responsible for JNK inhibition (not shown).
Negative_regulation (inhibition) of JNK
20) Confidence 0.30 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0

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