INT11698

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.64
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-A)
Anatomy Link Frequency
CD86 2
B18 2
cytotoxic T-lymphocytes 2
HLA-A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 99.84 Very High Very High Very High
Arthritis 2 83.84 Quite High
spinal inflammation 1 82.12 Quite High
antagonist 1 78.24 Quite High
Inflammation 6 75.00 Quite High
cytokine 19 49.36 Quite Low
cva 4 28.20 Quite Low
chemokine 6 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hookworm Infection 35 99.46 Very High Very High Very High
Dengue 21 98.90 Very High Very High Very High
Cancer 55 95.64 Very High Very High Very High
Disease 28 92.68 High High
Aggression 1 91.24 High High
Dengue Hemorrhagic Fever 139 90.20 High High
Infection 67 89.60 High High
Chronic Lymphoid Leukemia 1 89.36 High High
Prostate Cancer 46 89.20 High High
Bacterial Infection 2 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HLA-DM, -DO (peptide loading), HLA-DP, -DQ, -DR (antigen presentation), granzyme B, H, perforin and FCGR3A (CD16) (cytotoxicity) displayed increased expression, as did CD8, a marker of cytotoxic T-lymphocytes, while HLA-A and -C expression were not increased by NSAID treatment.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of HLA-A in cytotoxic T-lymphocytes associated with cinod
1) Confidence 0.67 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.82 Pain Relevance 0.60
Dengue virus, like other members of the Flaviviridae family, increases the expression of HLA class I and II molecules on infected cells [14].
Positive_regulation (increases) of Gene_expression (expression) of HLA associated with dengue
2) Confidence 0.06 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.10 Pain Relevance 0.04
These same hookworm-infected individuals also presented significantly down-regulated expression of CD86, CD1a, HLA-ABC, and HLA-DR.
Positive_regulation (presented) of Gene_expression (expression) of HLA-ABC in CD86 associated with hookworm infection
3) Confidence 0.05 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2654967 Disease Relevance 0.57 Pain Relevance 0
We described an endogenously produced HLA-A2-restricted peptide, which induced specific CTL responses in vitro [37].
Positive_regulation (induced) of Gene_expression (produced) of HLA-A2
4) Confidence 0.04 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 1.67 Pain Relevance 0
Target cells used were murine L cells transfected with HLA-B27, HLA-A3, HLA-A2, HLA B44, HLA B18, or pSV2neo vector alone.
Positive_regulation (transfected) of Gene_expression (transfected) of HLA-A3 in B18
5) Confidence 0.01 Published 1992 Journal J. Immunol. Section Abstract Doc Link 1588045 Disease Relevance 0.48 Pain Relevance 0.12

General Comments

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