INT117142

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 58
Total Number 59
Disease Relevance 45.02
Pain Relevance 6.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1)
Anatomy Link Frequency
leukocytes 4
fibroblasts 3
bladder 3
endothelial cells 3
macrophage 2
Thbs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1268 100.00 Very High Very High Very High
chemokine 50 100.00 Very High Very High Very High
Dextromethorphan 14 99.38 Very High Very High Very High
cytokine 193 96.60 Very High Very High Very High
cINOD 12 94.96 High High
Inflammatory response 145 92.96 High High
fibrosis 19 89.28 High High
Chronic pancreatitis 6 87.04 High High
Bioavailability 9 86.72 High High
addiction 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 5442 100.00 Very High Very High Very High
INFLAMMATION 1440 100.00 Very High Very High Very High
Malignant Neoplastic Disease 28 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 12 99.58 Very High Very High Very High
Adhesions 48 99.36 Very High Very High Very High
Reprotox - General 1 37 98.92 Very High Very High Very High
Bladder Cancer 277 98.78 Very High Very High Very High
Polyps 1 98.76 Very High Very High Very High
Injury 12 98.32 Very High Very High Very High
Melanoma 264 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PSC were isolated by outgrowth from normal mouse pancreas and expression of TSP-1 and TSP-2 was evaluated after serum-activation.
Gene_expression (expression) of TSP-1 in PSC associated with primary sclerosing cholangitis
1) Confidence 0.72 Published 2006 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 16181801 Disease Relevance 1.39 Pain Relevance 0.23
Treatment of Min mice with concentrations of sulindac sulfide that inhibit tumor formation increased the expression of Egr-1 and TSP-1 in colonic tissues and in the polyps of these mice.
Gene_expression (expression) of TSP-1 associated with cancer and polyps
2) Confidence 0.70 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227405 Disease Relevance 0.54 Pain Relevance 0.25
Densitometric quantitation of TSP-1 bands from three independent experiments showed that adding NEM before shear reduced TSP-1 protein depletion during shear by approximately 50% (data not shown).
Gene_expression (depletion) of TSP-1 protein in bands
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
It is of interest to consider why the TSP-1 contribution to activation of TGF-?
Gene_expression (contribution) of TSP-1
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
TSP-1 was detected with anti-TSP-1 mAb (Ab-11).
Gene_expression (detected) of TSP-1
5) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
The TSP-1 contribution in serum increases active TGF-?
Gene_expression (contribution) of TSP-1
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
Our data indicate that under conditions of optimal stirring and shear, the presence of TSP-1 at levels found in serum and platelet releasates enhances TGF-?
Gene_expression (presence) of TSP-1 in platelet
7) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
We tested whether TSP-1, like TGF-?
Gene_expression (tested) of TSP-1
8) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
The second hypothesis is that TSP-1 depletion limits the contribution of TSP-1 to TGF-?
Gene_expression (depletion) of TSP-1
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
TSP-1 was detected with anti-TSP-1 mAb (Ab-11).
Gene_expression (detected) of anti-TSP-1
10) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719874 Disease Relevance 0 Pain Relevance 0
deficient mice expressed high levels of TSP-1 while WT leukocytes express very little if any TSP-1 (Figure 5D).
Gene_expression (expressed) of TSP-1 in leukocytes
11) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.05 Pain Relevance 0.07
KO mice treated with GR1 antibody, little or no TSP-1 was detected (Figure 5C).
Gene_expression (detected) of TSP-1
12) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.18 Pain Relevance 0.12
deficiency suppresses tumor growth by increasing the expression of the matrix protein thrombospondin-1 (TSP-1) which inhibits angiogenesis and stimulates granulocyte migration [28].
Gene_expression (expression) of TSP-1 in granulocyte associated with cancer
13) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.56 Pain Relevance 0.28
TSP-1 was found in tumors in PPAR?
Gene_expression (found) of TSP-1 associated with cancer
14) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.31 Pain Relevance 0.16
Taken together, these findings suggest that in this model system, TSP-1 was produced predominantly by the inflammatory cells, and not by resident stromal cells.
Neg (not) Gene_expression (produced) of TSP-1 in stromal cells associated with inflammation
15) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 0.96 Pain Relevance 0.05
In contrast, little or no TSP-1 was detected in the tumors in PPAR?
Gene_expression (detected) of TSP-1 associated with cancer
16) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.28 Pain Relevance 0.15
deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess production of the endogenous angiogenesis inhibitor thrombospondin-1 and prevents tumor growth.
Gene_expression (production) of thrombospondin-1 associated with inflammation and cancer
17) Confidence 0.56 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1800345 Disease Relevance 1.19 Pain Relevance 0.22
Because TSP-1 can be expressed in several cell types, including tumor cells, endothelial cells and fibroblasts, we next determined the cellular origin for TSP-1 in the tumors of PPAR?
Gene_expression (expressed) of TSP-1 in fibroblasts associated with cancer
18) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.48 Pain Relevance 0.25
deficiency suppresses tumor growth by increasing the expression of the matrix protein thrombospondin-1 (TSP-1) which inhibits angiogenesis and stimulates granulocyte migration [28].
Gene_expression (expression) of thrombospondin-1 in granulocyte associated with cancer
19) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1800345 Disease Relevance 1.56 Pain Relevance 0.28
In summary, PSC may be an important source of both TSP-1 and TSP-2 in the pancreas in response to injury.
Gene_expression (source) of TSP-1 in pancreas associated with injury and primary sclerosing cholangitis
20) Confidence 0.56 Published 2006 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 16181801 Disease Relevance 1.34 Pain Relevance 0.25

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