INT117221

Context Info Confidence 0.65 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 9 Disease Relevance 4.39 Pain Relevance 1.83

cytosol (NOD2) plasma membrane (NOD2) enzyme binding (NOD2) cytoplasm (NOD2)

Anatomy Link Frequency HL-60 2 Paneth cells 2 NOD2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 73 100.00 Crohn's disease 72 99.50 Inflammatory stimuli 4 97.92 cytokine 57 82.88 anesthesia 1 82.08 Inflammatory mediators 3 81.04 antagonist 3 73.84 ischemia 1 69.20 Inflammatory response 10 63.68 Arthritis 1 57.96

Disease Link Frequency Relevance Heat INFLAMMATION 79 100.00 Disease 72 99.50 Inflammatory Bowel Disease 17 98.60 Crohn's Disease 24 96.84 Endotoxemia 5 94.16 Infection 15 87.12 Injury 10 86.60 Disease Susceptibility 9 78.56 Cv Unclassified Under Development 1 69.20 Reperfusion Injury 1 68.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Surprisingly, after 24 h, although Nod1 and Nod2 expression increased compared to the 6 h samples, all the studied Nod expression remained low compared to the non-exposed samples (Figure 6B).

Positive_regulation (increased) of Gene_expression (expression) of Nod2

1) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.10

We thus hypothesize that alternative splicing of the two novel isoforms contributes to the upregulation of NOD2 protein levels observed under inflammatory conditions and the high constitutive expression in distinct cell types, i.e. monocytic cells and, possibly, Paneth cells.

Positive_regulation (upregulation) of Gene_expression (expression) of NOD2 in Paneth cells associated with inflammation

2) Confidence 0.50 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.38 Pain Relevance 0.17

A genetic ablation of Nod2 in mice leads to a distinct defect in cryptdin (?

Positive_regulation (leads) of Gene_expression (ablation) of Nod2

3) Confidence 0.50 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.58 Pain Relevance 0.28

To determine to what extent the lipopolysaccharide-induced TNF-alpha production capacity in vivo and ex vivo is determined by polymorphisms in toll-like receptor-4 (TLR4), the TNF-alpha promoter region and Nod2, we screened for two TLR4 polymorphisms, a Nod2 polymorphism and the TNF-alpha promoter polymorphisms.

Positive_regulation (screened) of Gene_expression (polymorphism) of Nod2

4) Confidence 0.47 Published 2004 Journal Cytokine Section Abstract Doc Link 15016407 Disease Relevance 0.49 Pain Relevance 0.15

B phosphorylation upon PGN-ECndss treatment as well as IL-6 inducibility after UV exposure suggest a functional Nod1/Nod2-initiated NF?

Positive_regulation (functional) of Gene_expression (/) of Nod2

5) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.68 Pain Relevance 0.27

B phosphorylation upon PGN-ECndss treatment as well as IL-6 inducibility after UV exposure suggest a functional Nod1/Nod2-initiated NF?

Positive_regulation (suggest) of Gene_expression (/) of Nod2

6) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.68 Pain Relevance 0.27

and lipopolysaccharide (LPS) activate NOD2 (CARD15) gene expression in intestinal epithelial cell lines and primary intestinal epithelial cells as well as monocytic HL-60 cells [11,12].

Positive_regulation (activate) of Gene_expression (expression) of CARD15 in HL-60

7) Confidence 0.46 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.26 Pain Relevance 0.13

Tissue specific constitutive and inducible expression patterns of NOD2 have been described that result from complex regulatory events for which the molecular mechanisms are not yet fully understood.

Positive_regulation (inducible) of Gene_expression (expression) of NOD2

8) Confidence 0.46 Published 2007 Journal BMC Genomics Section Abstract Doc Link PMC2228316 Disease Relevance 0.20 Pain Relevance 0.05

Crohn's disease-associated mutations in NOD2 result in defective NF kappa B activation, suggesting that Crohn's disease may represent, in part, a defect in innate immunity [4].

Positive_regulation (activation) of Gene_expression (result) of NOD2 associated with crohn's disease and disease

9) Confidence 0.29 Published 2004 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC428583 Disease Relevance 1.12 Pain Relevance 0.43

General Comments

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