INT117434

Context Info Confidence 0.30 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.39 Pain Relevance 0.20

cytosol (IKBKB) nucleus (IKBKB) cytoplasm (IKBKB)

IKBKB (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 2 97.88

Disease Link Frequency Relevance Heat INFLAMMATION 1 97.64 Apoptosis 5 92.88 Necrosis 2 92.68 Cancer 9 92.32 Carcinoma 4 91.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, the nonsteroidal anti-inflammatory drug (NSAID) sulindac and its metabolites have been shown to inhibit the NF-kappaB-mediated survival signals through inhibition of IKK-beta by their direct interaction.

Negative_regulation (inhibition) of IKK-beta Binding (interaction) of associated with inflammation and cinod

1) Confidence 0.30 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15033733 Disease Relevance 1.39 Pain Relevance 0.20

General Comments

This test has worked.