INT117568

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.13
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Dspp (Mus musculus)
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 1 62.48 Quite High
Analgesic 1 59.84 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Granuloma 1 65.84 Quite High
Hyperalgesia 1 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a previous study, we reported a new pyrazolo pyrimidine derivative, N(4)-benzyl-N(6),N(6)-dimethyl-1-1(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidine-6,4-diamine (DPP), which inhibited potently cyclooxygenase-2 activity in intact cell assays with minor activity against cyclooxygenase-1 (IC(50)=0.9 nM for cyclooxygenase-2 versus IC(50)=59.6 nM for cyclooxygenase-1).
DPP Negative_regulation (inhibited) of cyclooxygenase-2
1) Confidence 0.11 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15044055 Disease Relevance 0.13 Pain Relevance 0.12

General Comments

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