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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.13
Pain Relevance 0.12

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lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Dspp (Mus musculus)
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 1 62.48 Quite High
Analgesic 1 59.84 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Granuloma 1 65.84 Quite High
Hyperalgesia 1 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a previous study, we reported a new pyrazolo pyrimidine derivative, N(4)-benzyl-N(6),N(6)-dimethyl-1-1(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidine-6,4-diamine (DPP), which inhibited potently cyclooxygenase-2 activity in intact cell assays with minor activity against cyclooxygenase-1 (IC(50)=0.9 nM for cyclooxygenase-2 versus IC(50)=59.6 nM for cyclooxygenase-1).
DPP Negative_regulation (inhibited) of cyclooxygenase-2
1) Confidence 0.11 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15044055 Disease Relevance 0.13 Pain Relevance 0.12

General Comments

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