INT117710

Context Info Confidence 0.19 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.13 Pain Relevance 1.48

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)

Anatomy Link Frequency TM1 1 Slc12a2 (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 14 100.00 Serotonin 8 100.00 antidepressant 6 99.70 antagonist 6 95.04 Potency 6 94.36 Nucleus accumbens 4 87.52 cocaine 4 80.72 fluoxetine 2 67.36 sodium channel 1 54.80 tetrodotoxin 1 52.96

Disease Link Frequency Relevance Heat Respiratory Tract Infection 2 66.76 Pressure And Volume Under Development 5 5.00 Targeted Disruption 5 5.00 Epilepsy 2 5.00 Stress 2 5.00 Schizophrenia 1 5.00 Depression 1 5.00 Drug Dependence 1 5.00 Injury 1 5.00 Neuropathic Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The model underlying H4 (mc4, only NKCC1) predicts a small decrease in [Cl?]

NKCC1 Binding (underlying) of

1) Confidence 0.19 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0

Amphetamine is known to increase dopamine (DA) release by acting directly on dopamine transporters (DAT), primarily through a mechanism that is independent of impulse flow.

transporters Binding (acting) of associated with dopamine

2) Confidence 0.17 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15056292 Disease Relevance 0 Pain Relevance 0.54

In previous studies examining the structural determinants of antidepressant and substrate recognition by serotonin transporters (SERTs), we identified Tyr-95 in transmembrane segment 1 (TM1) of human SERT as a major determinant of binding for several antagonists, including racemic citalopram ((RS)-CIT).

transporters Binding (recognition) of in TM1 associated with antidepressant, antagonist and serotonin

3) Confidence 0.00 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16272152 Disease Relevance 0.06 Pain Relevance 0.38

Unlike hSERT or mSERT, analogous substitutions in mouse dopamine transporter (V152M) or human norepinephrine transporter (V148M) result in transporters that bind substrate but are deficient in the subsequent translocation of the substrate.

transporters Binding (bind) of associated with dopamine

4) Confidence 0.00 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16272152 Disease Relevance 0.07 Pain Relevance 0.57

General Comments

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