INT117710

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Context Info
Confidence 0.19
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.13
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)
Anatomy Link Frequency
TM1 1
Slc12a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 14 100.00 Very High Very High Very High
Serotonin 8 100.00 Very High Very High Very High
antidepressant 6 99.70 Very High Very High Very High
antagonist 6 95.04 Very High Very High Very High
Potency 6 94.36 High High
Nucleus accumbens 4 87.52 High High
cocaine 4 80.72 Quite High
fluoxetine 2 67.36 Quite High
sodium channel 1 54.80 Quite High
tetrodotoxin 1 52.96 Quite High
Disease Link Frequency Relevance Heat
Respiratory Tract Infection 2 66.76 Quite High
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Epilepsy 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The model underlying H4 (mc4, only NKCC1) predicts a small decrease in [Cl?]
NKCC1 Binding (underlying) of
1) Confidence 0.19 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
Amphetamine is known to increase dopamine (DA) release by acting directly on dopamine transporters (DAT), primarily through a mechanism that is independent of impulse flow.
transporters Binding (acting) of associated with dopamine
2) Confidence 0.17 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15056292 Disease Relevance 0 Pain Relevance 0.54
In previous studies examining the structural determinants of antidepressant and substrate recognition by serotonin transporters (SERTs), we identified Tyr-95 in transmembrane segment 1 (TM1) of human SERT as a major determinant of binding for several antagonists, including racemic citalopram ((RS)-CIT).
transporters Binding (recognition) of in TM1 associated with antidepressant, antagonist and serotonin
3) Confidence 0.00 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16272152 Disease Relevance 0.06 Pain Relevance 0.38
Unlike hSERT or mSERT, analogous substitutions in mouse dopamine transporter (V152M) or human norepinephrine transporter (V148M) result in transporters that bind substrate but are deficient in the subsequent translocation of the substrate.
transporters Binding (bind) of associated with dopamine
4) Confidence 0.00 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16272152 Disease Relevance 0.07 Pain Relevance 0.57

General Comments

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