INT1178

Context Info Confidence 0.60 First Reported 1975 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 16 Total Number 16 Disease Relevance 7.71 Pain Relevance 2.41

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren) intracellular (Ren) response to stress (Ren)

Anatomy Link Frequency plasma 18 liver 2 head 2 sympathetic nervous system 2 Ren (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 19 99.52 fibrosis 16 98.64 antagonist 2 98.44 Inflammation 20 98.12 narcan 6 96.80 analgesia 4 94.64 ischemia 2 92.48 Versed 2 91.76 dexamethasone 1 87.68 headache 1 85.68

Disease Link Frequency Relevance Heat Hypertension 16 100.00 Syndrome 2 100.00 Hypotension 4 99.90 Coronary Heart Disease 18 99.76 Left Ventricular Hypertrophy 1 99.52 Pressure And Volume Under Development 8 99.28 Hyperuricemia 2 99.16 Fibrosis 14 98.64 Bordatella Infection 4 98.32 INFLAMMATION 23 98.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Propranolol partially blocked the increase in plasma renin concentration produced by anesthetics.

Positive_regulation (increase) of Gene_expression (produced) of plasma renin in plasma

1) Confidence 0.60 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3894036 Disease Relevance 0.27 Pain Relevance 0.17

The source of myocardial renin maybe direct cardiac renin gene expression, or plasma renin of renal origin.

Positive_regulation (direct) of Gene_expression (expression) of renin in plasma

2) Confidence 0.50 Published 2001 Journal Basic Res. Cardiol. Section Abstract Doc Link 11770086 Disease Relevance 0.10 Pain Relevance 0

The morphological characteristics of the hamartomatous abnormality are described and evidences are put forward which would suggest that the liver lesion might have been the site of the abnormal renin production which was responsible for the systemic arterial hypertension.

Positive_regulation (responsible) of Gene_expression (production) of renin in liver associated with pressure and volume under development

3) Confidence 0.49 Published 1975 Journal Virchows Arch A Pathol Anat Histol Section Abstract Doc Link 804756 Disease Relevance 0.60 Pain Relevance 0.09

The intracerebral administration of renin and angiotensin II produces an increase in latencies to thermoalgesic stimuli; this is reduced, as is immobilization stress, by naloxone and saralasin.

Positive_regulation (increase) of Gene_expression (produces) of renin associated with stress and narcan

4) Confidence 0.47 Published 1986 Journal Pain Section Abstract Doc Link 3540814 Disease Relevance 0.43 Pain Relevance 0.58

Pharmacological evidence that the sympathetic nervous system mediates the increase in renin secretion produced by immobilization and head-up tilt in rats.

Positive_regulation (increase) of Gene_expression (produced) of renin in head

5) Confidence 0.47 Published 1988 Journal Neuropharmacology Section Title Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.22

On the other hand, the increase in secretion of renin produced by inactin anesthesia does not appear to be mediated by the sympathetic nervous system.

Positive_regulation (increase) of Gene_expression (produced) of renin in sympathetic nervous system associated with anesthesia

6) Confidence 0.47 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.24

It is suggested that this increase is hardly due to an interception of the feedback, but to the concomitant fall in blood pressure, as a similar hypotension and increase in plasma renin is produced by dihydralazine.

Positive_regulation (increase) of Gene_expression (produced) of plasma renin in plasma associated with hypotension

7) Confidence 0.44 Published 1975 Journal Acta Pathol Microbiol Scand A Section Abstract Doc Link 170788 Disease Relevance 0.51 Pain Relevance 0

The source of myocardial renin maybe direct cardiac renin gene expression, or plasma renin of renal origin.

Positive_regulation (direct) of Gene_expression (source) of plasma renin in plasma

8) Confidence 0.44 Published 2001 Journal Basic Res. Cardiol. Section Abstract Doc Link 11770086 Disease Relevance 0.10 Pain Relevance 0

There was a significant increase in plasma renin activity and prolactin level in the stressed rats.

Positive_regulation (increase) of Gene_expression (level) of plasma renin in plasma

9) Confidence 0.42 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994844 Disease Relevance 0.88 Pain Relevance 0.25

Losartan and PD-123319 each increased vascular renin distribution in both kidneys.

Positive_regulation (increased) of Gene_expression (distribution) of vascular renin

10) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17442727 Disease Relevance 0.79 Pain Relevance 0.08

During an investigation of the role of the mediobasal hypothalamus in the regulation of renin secretion from the kidneys, we found that lesions of the ventromedial nuclei prevented the increase in plasma renin activity produced by p-chloroamphetamine.

Positive_regulation (increase) of Gene_expression (produced) of plasma renin in plasma

11) Confidence 0.41 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3041306 Disease Relevance 0 Pain Relevance 0.08

In the present study, we tested the effects of bilateral electrolytic lesions of the ventromedial nuclei on the increase in plasma renin activity produced in sham-operated rats by immobilization, head-up tilt under inactin anesthesia, and a low-sodium diet.

Positive_regulation (increase) of Gene_expression (produced) of plasma renin in plasma associated with anesthesia

12) Confidence 0.41 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3041306 Disease Relevance 0 Pain Relevance 0.10

Is low-renin hypertension an overdiagnosed syndrome?

Positive_regulation (syndrome) of Gene_expression (hypertension) of renin associated with syndrome and hypertension

13) Confidence 0.40 Published 1978 Journal Geriatrics Section Title Doc Link 624453 Disease Relevance 0.60 Pain Relevance 0.11

Left ventricular hypertrophy was associated with an increase in ANP expression and low plasma renin activity, indicative of a volume overload in post-infarct GK rats, a feature that was not present in non-diabetic Wistar rats.

Positive_regulation (increase) of Gene_expression (expression) of renin in plasma associated with left ventricular hypertrophy and diabetes mellitus

14) Confidence 0.24 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.11 Pain Relevance 0.04

In conditions in which there is overactivity of the renin-angiotensin system (RAS), such as mild hyperuricemia and protein overload, arteriolopathy is associated with increased glomerular pressure and reduced glomerular plasma flow that results in post-glomerular ischemia and tubulointerstitial injury.

Positive_regulation (overactivity) of Gene_expression (overactivity) of renin-angiotensin system in plasma associated with hyperuricemia, ischemia and injury

15) Confidence 0.23 Published 2003 Journal Kidney Int. Suppl. Section Abstract Doc Link 12969121 Disease Relevance 1.39 Pain Relevance 0.26

The rat and human renin-angiotensin systems do not interact, so the hypertension and vasculopathy exhibited by these rats is the result of the overexpression of the human renin-angiotensin system.

Positive_regulation (overexpression) of Gene_expression (overexpression) of renin associated with hypertension

16) Confidence 0.20 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.91 Pain Relevance 0.20

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