INT117836

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 0.62
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPHB3) plasma membrane (EPHB3)
Anatomy Link Frequency
Caco-2 1
neurons 1
embryonic kidney 1
EPHB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 786 99.56 Very High Very High Very High
antagonist 285 98.78 Very High Very High Very High
analgesia 3 90.04 High High
Clonidine 1 89.76 High High
Spinal cord 1 87.24 High High
Hyperalgesia 1 85.64 High High
agonist 191 83.28 Quite High
Inflammation 14 83.24 Quite High
Pain 3 80.00 Quite High
tetrodotoxin 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 85.64 High High
INFLAMMATION 19 83.24 Quite High
Pain 3 80.00 Quite High
Neuroblastoma 22 75.00 Quite High
Glioma 20 12.96 Low Low
Hypoglycemia 5 9.12 Low Low
Diabetes Mellitus 25 5.00 Very Low Very Low Very Low
Asthma 15 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differentiation increased expression of EPHB2 and EPHB3.
Gene_expression (expression) of EPHB3
1) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.13
Inhibition of N-[methyl-3H]4-phenylpyridinium ([3H]MPP+) uptake by various compounds into Caco-2 cells and into cells (HEK-293 or CHO) that were stably transfected with hOCT1, hOCT2 or hOCT3 was compared.
Gene_expression (transfected) of HEK-293 in Caco-2
2) Confidence 0.03 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16263091 Disease Relevance 0 Pain Relevance 0.15
In URAT1-stably expressing HEK293 (HEK293-URAT1) cells, salicylate inhibited [14C] urate uptake dose-dependently (IC50, 23.9 microM).
Gene_expression (expressing) of HEK293
3) Confidence 0.03 Published 2010 Journal Nihon Jinzo Gakkai Shi Section Abstract Doc Link 20560471 Disease Relevance 0.07 Pain Relevance 0.11
In URAT1-stably expressing HEK293 (HEK293-URAT1) cells, salicylate inhibited [14C] urate uptake dose-dependently (IC50, 23.9 microM).
Gene_expression (expressing) of HEK293
4) Confidence 0.02 Published 2010 Journal Nihon Jinzo Gakkai Shi Section Abstract Doc Link 20560471 Disease Relevance 0.07 Pain Relevance 0.11
Using membranes from HEK 293 cells expressing the human recombinant A2B receptor, [3H]OSIP339391 was characterized in kinetic, saturation and competition binding experiments.
Gene_expression (expressing) of HEK 293
5) Confidence 0.02 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0 Pain Relevance 0.26
Radioligand binding studies showed that it binds to recombinant A2B receptors in membranes of stably transfected HEK 293 cells.
Gene_expression (transfected) of HEK 293
6) Confidence 0.02 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0 Pain Relevance 0.30
Na+ currents in human embryonic kidney cells (HEK293) transfected with hNbR1 or hNbR1-2 showed electrophysiological properties similar to those for TTX-R I(Na) in NB-1 cells.
Gene_expression (transfected) of HEK293 in embryonic kidney
7) Confidence 0.02 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16115203 Disease Relevance 0.14 Pain Relevance 0.13
HEK-293 cell membranes recombinantly expressing the human adenosine A2B receptor (Bmax = 1.6 pmol per milligram protein detected with [3H]DPCPX) were purchased from Perkin Elmer Life Sciences, Boston, USA.
Gene_expression (expressing) of HEK-293 associated with adenocard
8) Confidence 0.01 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0 Pain Relevance 0.09
For the characterization of the new antagonist radioligand [3H] PSB-298 saturation and kinetics studies in HEK-293 cells recombinantly expressing the human adenosine A2B receptor in high density were performed.
Gene_expression (expressing) of HEK-293 associated with adenocard and antagonist
9) Confidence 0.01 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0 Pain Relevance 0.39
Commercially available membranes from HEK-293 cells expressing the human adenosine A2B receptor in a high density (Bmax value of 1.6 pmol per milligram protein) were used to evaluate the new antagonist radioligand.
Gene_expression (expressing) of HEK-293 associated with adenocard and antagonist
10) Confidence 0.01 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0 Pain Relevance 0.15
In addition, [3H]OSIP339391 may label a second, low affinity, binding site in HEK-293 cells transfected with the human adenosine A2B receptor, since the saturation assay showed a non-linear Rosenthal plot.
Gene_expression (transfected) of HEK-293 associated with adenocard
11) Confidence 0.01 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0 Pain Relevance 0.55
Saturation experiments demonstrated that [3H]PSB-298 bound to a single class of binding sites in the HEK-293 cell membranes recombinantly expressing the human adenosine A2B receptor with a KD value of 60 ± 1 nM and an apparent Bmax value of 3,511 ± 93 fmol per milligram protein (Figure 6).
Gene_expression (expressing) of HEK-293 associated with adenocard
12) Confidence 0.01 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0 Pain Relevance 0.25
Adenosine analogs inhibit TRPV1-mediated Ca(2+) entry in human embryonic kidney (HEK293) cells stably expressing TRPV1 (HEK/TRPV1) and DRG neurons.
Gene_expression (expressing) of HEK293 in neurons associated with adenocard
13) Confidence 0.00 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15071115 Disease Relevance 0.33 Pain Relevance 0.83

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