INT117912

Context Info Confidence 0.04 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.89 Pain Relevance 0.13

nucleoplasm (CREB1, MAPK1) mitochondrion (CREB1, MAPK1) signal transduction (CREB1, MAPK1) nucleus (CREB1, MAPK1) transcription factor binding (CREB1, MAPK1) Golgi apparatus (MAPK1)

CREB1 (Homo sapiens) MAPK1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 1 91.64 cINOD 1 84.64

Disease Link Frequency Relevance Heat Colon Cancer 5 86.52 INFLAMMATION 1 84.40 Apoptosis 5 78.40 Stress 1 69.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Studies with pharmacological inhibitors revealed that cAMP-dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A.

CREB Positive_regulation (required) of Positive_regulation (activation) of ERK1/2

1) Confidence 0.04 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.89 Pain Relevance 0.13

General Comments

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