INT117920

Context Info Confidence 0.38 First Reported 2003 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 14 Total Number 15 Disease Relevance 8.75 Pain Relevance 4.31

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14) nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)

Anatomy Link Frequency neurons 1 adipocytes 1 lung 1 MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 264 99.84 Inflammation 265 99.38 Central nervous system 85 99.32 agonist 25 98.86 cINOD 12 96.16 Osteoarthritis 198 95.68 cannabis 1 89.76 dexamethasone 43 88.24 rheumatoid arthritis 92 86.56 Abeta 4 84.92

Disease Link Frequency Relevance Heat Disease 80 99.88 Obesity 90 99.78 Apoptosis 108 99.60 Hyperplasia 6 99.60 INFLAMMATION 315 99.38 Alzheimer's Dementia 10 99.34 Lung Injury 9 99.32 Arthritis 13 99.00 Stress 32 97.76 Osteoarthritis 170 95.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Whereas the free radical scavenging and antioxidant properties of PE are well established [39], emerging literature reports suggest that their anti-arthritic effects may also be ascribed to their ability to modulate many signal transduction pathways including p38-MAPK and NF-?

Regulation (modulate) of p38 associated with arthritis

1) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.79 Pain Relevance 0.30

Thus, we show for the first time that the production of TNFalpha in mature human adipocytes is mainly dependent upon two pathways: NFkappaB and p38 MAP Kinase.

Regulation (dependent) of p38 MAP Kinase in adipocytes associated with obesity

2) Confidence 0.30 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.16 Pain Relevance 0

To investigate the potential mechanisms underlying the anti-inflammatory activity of BOL-303242-X, its effects on the MAPKs p38 and JNK were determined in HCEpiCs.

Regulation (effects) of p38 associated with inflammation

3) Confidence 0.18 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.16 Pain Relevance 0.62

The p38 MAPK family as regulators of proinflammatory cytokine production

Regulation (regulators) of p38 associated with cytokine

4) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.61 Pain Relevance 0.47

Such results indicate the potential for targeting p38?

Regulation (targeting) of p38

5) Confidence 0.15 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.40 Pain Relevance 0.27

The involvement of signaling pathways (JNK, p38, and Erk1/2 MAP-kinases, JAK2 and JAK3, PKC, and transcription factor NF-?

Regulation (involvement) of p38

6) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.39 Pain Relevance 0.24

Therefore, we studied the effect of arsenic trioxide on p38 MAP kinase in regards to apoptosis.

Regulation (effect) of p38 MAP kinase associated with apoptosis

7) Confidence 0.13 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2864039 Disease Relevance 0.70 Pain Relevance 0

Modulation of p38?

Regulation (Modulation) of p38

8) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.97 Pain Relevance 0.50

MAPK inhibitors provides the required foundation for drug discovery campaigns targeting p38?

Regulation (targeting) of p38

9) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2604896 Disease Relevance 0.33 Pain Relevance 0.34

Immunoblots and transcriptional reporter assays using specific inhibitors, as well as expression of constitutively active forms of MEK1 and MKK3, showed that c-IAP2 induction by cAMP is regulated predominantly through ERK1/2 and p38 MAPK and suggested involvement of p90 ribosomal protein S6 kinase and mitogen and stress response kinase-1 as well.

Regulation (regulated) of p38 associated with stress

10) Confidence 0.07 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.90 Pain Relevance 0.11

The MEK (MAP kinase kinase) and extracellular signal regulated kinases (ERK) pathway primarily responds to cellular proliferation signals, while the p38 MAP kinases and c-Jun N-terminal kinases are modulated by cytokines, growth factors and a variety of cellular stress signals [97].

Regulation (modulated) of p38 associated with stress, hyperplasia and cytokine

11) Confidence 0.06 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.27 Pain Relevance 0.16

Reductions in MFI values for p-AKT, p-p38, p-JNK, p-PLC?

Regulation (values) of p38

12) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0 Pain Relevance 0.36

Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement.

Regulation (involvement) of p38 MAP kinase in neurons associated with alzheimer's dementia

13) Confidence 0.03 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16490313 Disease Relevance 0.80 Pain Relevance 0.41

-Smad signaling, however, led to down-regulation of p38 by including MAPK phosphatase-1 (MKP-1), thereby acting as a negative regulator for MUC5AC induction (248).

Regulation (regulation) of p38

14) Confidence 0.03 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 1.08 Pain Relevance 0.15

Matot and colleagues [25] evaluated MAPK activation in the reperfused lung, comparing the effects of the highly selective A3AR agonist MRS3558 with that of the moderately selective agonist IB-MECA on lung injury and apoptosis and determined the modulation of MAPK (ERK1, ERK2, p38, and JNK) pathways after A3AR activation in a feline model of lung I/R.

Spec (determined) Regulation (modulation) of p38 in lung associated with lung injury, agonist and apoptosis

15) Confidence 0.02 Published 2007 Journal Crit Care Section Body Doc Link PMC2206506 Disease Relevance 1.17 Pain Relevance 0.37

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