INT117921

Context Info Confidence 0.44 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 14 Disease Relevance 9.93 Pain Relevance 4.18

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14) nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)

Anatomy Link Frequency chondrocytes 6 lymphocytes 2 A549 2 MAPK14 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 3 99.48 Osteoarthritis 652 99.40 Opioid 4 96.32 cytokine 72 95.84 rheumatoid arthritis 112 94.12 agonist 3 91.44 Inflammation 168 90.76 analgesia 2 90.24 Endocannabinoid 1 87.88 IPN 2 85.60

Disease Link Frequency Relevance Heat Osteoarthritis 629 99.40 Targeted Disruption 20 99.40 Multiple Myeloma 6 98.68 Apoptosis 210 98.44 Disease 73 96.72 Fever 41 94.84 Rheumatoid Arthritis 157 94.12 Frailty 40 93.84 INFLAMMATION 162 90.76 Adhesions 9 89.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Secretion requires intracellular calcium mobilization and activation of phosphinositol-3 kinase and p38 mitogen activated kinase.

Positive_regulation (requires) of Positive_regulation (activation) of p38

1) Confidence 0.44 Published 2007 Journal Curr Rheumatol Rep Section Abstract Doc Link 18177605 Disease Relevance 0.49 Pain Relevance 1.20

-induced activation of p38-MAPK in human OA chondrocytes

Positive_regulation (induced) of Positive_regulation (activation) of p38 in chondrocytes associated with osteoarthritis

2) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.04 Pain Relevance 0.44

-induced activation of p38?

Positive_regulation (induced) of Positive_regulation (activation) of p38

3) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.06 Pain Relevance 0.58

-induced activation of p38-MAPK isoforms in human OA chondrocytes.

Positive_regulation (induced) of Positive_regulation (activation) of p38 in chondrocytes associated with osteoarthritis

4) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.71 Pain Relevance 0.35

-induced activation of p38-MAPK compared to the level noted in cells with knockdown expression of MKK6.

Positive_regulation (induced) of Positive_regulation (activation) of p38

5) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.54 Pain Relevance 0.27

-induced activation of p38?

Positive_regulation (induced) of Positive_regulation (activation) of p38

6) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.62 Pain Relevance 0.31

-induced activation of p38-MAPK in human OA chondrocytes.

Positive_regulation (induced) of Positive_regulation (activation) of p38 in chondrocytes associated with osteoarthritis

7) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.61 Pain Relevance 0.31

Our results demonstrate a novel mechanism of sulindac-induced apoptosis in human MM cells, namely, accumulation of p53, Bax, and Bak in mitochondria mediated by p38 MAPK activation downstream of ROS production.

Positive_regulation (mediated) of Positive_regulation (activation) of p38 associated with multiple myeloma and apoptosis

8) Confidence 0.34 Published 2007 Journal Apoptosis Section Abstract Doc Link 17136320 Disease Relevance 1.12 Pain Relevance 0

Studies with pharmacological inhibitors revealed that cAMP-dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A.

Positive_regulation (required) of Positive_regulation (activation) of p38

9) Confidence 0.28 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.89 Pain Relevance 0.13

Furthermore, arsenic trioxide modulated caspase 3 activity and induced p38 MAP kinase activation in A549 cells.

Positive_regulation (induced) of Positive_regulation (activation) of p38 MAP kinase in A549

10) Confidence 0.24 Published 2010 Journal International Journal of Environmental Research and Public Health Section Abstract Doc Link PMC2864039 Disease Relevance 0.61 Pain Relevance 0

Activation of p38 was also significantly reduced in the LPS treated synoviocytes, and SNP treated Raw 264.7 cells and synoviocytes, but the expression ERK and p38 was also reduced, indicating that blocking of the activation of p38 and ERK was not specific (Fig. 1A and 1B).

Positive_regulation (reduced) of Positive_regulation (Activation) of p38

11) Confidence 0.08 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.06 Pain Relevance 0.03

In addition to p38 and JNK MAPK activation, we observed AKT and STAT activation in CD3+ lymphocytes.

Positive_regulation (activation) of Positive_regulation (activation) of p38 in lymphocytes

12) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 1.04 Pain Relevance 0.49

Indeed, our recent studies have shown that activation of the p38, ERK, and JNK MAP kinases is required for the chondrogenic induction and maintenance of TGF-?

Positive_regulation (required) of Positive_regulation (activation) of p38

13) Confidence 0.07 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.23 Pain Relevance 0

Hypericin induces apoptosis by triggering the release of cytochrome c after light excitation through a process requiring the activation of p38 MAPK, which it is known to induce an up-regulation of COX-2 [23, 151].

Positive_regulation (requiring) of Positive_regulation (activation) of p38 associated with apoptosis

14) Confidence 0.05 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.90 Pain Relevance 0.08

General Comments

This test has worked.