INT117926

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 3.25
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BIRC2) intracellular (BIRC2) cytoplasm (BIRC2)
Anatomy Link Frequency
colon 2
T84 2
BIRC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 99.98 Very High Very High Very High
cINOD 4 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colon Cancer 20 99.84 Very High Very High Very High
Apoptosis 20 96.32 Very High Very High Very High
INFLAMMATION 4 95.64 Very High Very High Very High
Stress 4 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with several different cAMP agonists stimulated phosphorylation of CRE-binding protein (CREB) and activated expression of c-IAP2 in a CREB-dependent manner.
Positive_regulation (stimulated) of Gene_expression (expression) of c-IAP2 associated with agonist
1) Confidence 0.48 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.82 Pain Relevance 0.14
We conclude that cAMP can induce c-IAP2 expression in colon cancer cells through CREB phosphorylation and CRE-dependent transcription in a manner that involves activation of ERK1/2 and p38 MAPK.
Positive_regulation (induce) of Gene_expression (expression) of c-IAP2 in colon associated with colon cancer
2) Confidence 0.48 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.85 Pain Relevance 0.09
In this study, we used T84 human colon cancer cells to define the pathway by which increases in cAMP induce c-IAP2 expression.
Positive_regulation (induce) of Gene_expression (expression) of c-IAP2 in T84 associated with colon cancer
3) Confidence 0.48 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.78 Pain Relevance 0.14
Treatment with several different cAMP agonists stimulated phosphorylation of CRE-binding protein (CREB) and activated expression of c-IAP2 in a CREB-dependent manner.
Positive_regulation (activated) of Gene_expression (expression) of c-IAP2 associated with agonist
4) Confidence 0.32 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.80 Pain Relevance 0.14

General Comments

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