INT11794

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Context Info
Confidence 0.76
First Reported 1991
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 27
Total Number 30
Disease Relevance 17.31
Pain Relevance 10.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cd2) protein complex (Cd2)
Anatomy Link Frequency
macrophages 2
external 2
juvenile 2
leukocyte 2
lymphocytes 2
Cd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 19 100.00 Very High Very High Very High
tetrodotoxin 16 100.00 Very High Very High Very High
anesthesia 3 99.96 Very High Very High Very High
cINOD 22 99.92 Very High Very High Very High
qutenza 153 99.84 Very High Very High Very High
Acupuncture 120 99.84 Very High Very High Very High
rheumatoid arthritis 25 99.80 Very High Very High Very High
Neuropathic pain 10 99.36 Very High Very High Very High
aspirin 9 99.00 Very High Very High Very High
spinal inflammation 8 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 112 100.00 Very High Very High Very High
INFLAMMATION 30 99.80 Very High Very High Very High
Rheumatoid Arthritis 25 99.80 Very High Very High Very High
Adhesions 18 99.78 Very High Very High Very High
Lyme Disease 8 99.56 Very High Very High Very High
Neuropathic Pain 11 99.36 Very High Very High Very High
Low Back Pain 8 98.84 Very High Very High Very High
Cv Unclassified Under Development 86 98.80 Very High Very High Very High
Systemic Lupus Erythematosus 8 97.88 Very High Very High Very High
Obesity 1 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In spite of elaborate studies on the role of CD2 and CD2R in adhesion and stimulation of T cells in vitro, no instances of CD2R expression in vivo were known to date.
Gene_expression (expression) of CD2R in T cells associated with adhesions
1) Confidence 0.76 Published 1991 Journal Scand. J. Immunol. Section Abstract Doc Link 1715605 Disease Relevance 0.90 Pain Relevance 0.32
Expression of the CD2 activation epitope T11-3 (CD2R) on T cells in rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease: phenotypic and functional analysis.
Gene_expression (Expression) of CD2 in juvenile associated with spinal inflammation, lyme disease, rheumatoid arthritis and systemic lupus erythematosus
2) Confidence 0.76 Published 1991 Journal Scand. J. Immunol. Section Title Doc Link 1715605 Disease Relevance 0.93 Pain Relevance 0.34
Expression of the CD2 activation epitope T11-3 (CD2R) on T cells in rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease: phenotypic and functional analysis.
Gene_expression (Expression) of CD2R in juvenile associated with spinal inflammation, lyme disease, rheumatoid arthritis and systemic lupus erythematosus
3) Confidence 0.76 Published 1991 Journal Scand. J. Immunol. Section Title Doc Link 1715605 Disease Relevance 0.95 Pain Relevance 0.35
In vivo, expression of CD2R was restricted to T cells, not limited to a particular T-cell subset and not correlated with the expression of p55 interleukin 2R (IL-2R) (CD25) or major histocompatibility complex (MHC) class II molecules.
Gene_expression (expression) of CD2R in T-cell
4) Confidence 0.76 Published 1991 Journal Scand. J. Immunol. Section Abstract Doc Link 1715605 Disease Relevance 0.95 Pain Relevance 0.34
Animals, Hg2+, Cd2+ and gentamicin treatment protocols
Gene_expression (Animals) of Cd2
5) Confidence 0.59 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1810561 Disease Relevance 0.20 Pain Relevance 0.03
Effects of gentamicin and Cd2+ on renal cell viability
Gene_expression (Effects) of Cd2
6) Confidence 0.51 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1810561 Disease Relevance 0.25 Pain Relevance 0.03
The basal miniature EPSC amplitude was similar in the presence of Cd2+, in the absence of external Ca2+ and in normal ACSF (32 ± 4 pA, 31 ± 2 pA and 28 ± 2 pA, p = 0.3).
Gene_expression (presence) of Cd2 in external
7) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987996 Disease Relevance 0 Pain Relevance 0.16
Note also that the [Ca2+]i response to capsaicin in the presence of Cd2+ often failed to fully recover. c In Ca2+-free solution, capsazepine (10 ?
Gene_expression (presence) of Cd2 associated with qutenza
8) Confidence 0.42 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.08 Pain Relevance 0.72
Alefacept is a selective immunomodulating, antipsoriatic drug that blocks the LFA-3/CD2 interaction necessary for the activation and proliferation of memory effector T cells by binding to CD2 expressed on the T cell surface.
Gene_expression (expressed) of CD2 in effector T cells associated with psoriasis
9) Confidence 0.42 Published 2005 Journal Expert Opin Drug Saf Section Abstract Doc Link 16255657 Disease Relevance 0.79 Pain Relevance 0.10
M) also produced an increase in the rate of miniature EPSCs in the presence of Cd2+ (p = 0.03, n = 6) which was not significantly different to that produced in its absence (n = 14) (Figure 5, p = 0.1).
Gene_expression (produced) of Cd2
10) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987996 Disease Relevance 0 Pain Relevance 0.13
In all neurons tested, increasing external potassium ([K+]ext = 25 mM) produced an increase in the rate of miniature EPSCs in normal ACSF (p = 0.04, n = 4), but not in the presence of Cd2+ (30 ?
Gene_expression (presence) of Cd2 in external
11) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987996 Disease Relevance 0.05 Pain Relevance 0.35
Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa.
Gene_expression (expression) of LFA-1 associated with aspirin, inflammation and cinod
12) Confidence 0.26 Published 1994 Journal Am. J. Physiol. Section Title Doc Link 7513960 Disease Relevance 0.60 Pain Relevance 0.43
We conclude that the adhesion molecules LFA-1 and ICAM-1 are expressed in the normal gastric mucosa and that the number of ICAM-1-stained blood vessels increase rapidly after NSAID treatment.
Gene_expression (expressed) of LFA-1 in blood vessels associated with cinod and adhesions
13) Confidence 0.26 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7513960 Disease Relevance 0.48 Pain Relevance 0.65
M Cd2+, which produced robust signaling to CREB (Fig. 4 D).
Gene_expression (produced) of Cd2
14) Confidence 0.25 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0.07
Gadolinium (0.5 mM) blocks both voltage-gated Ca2+ channels and TRPV1, and Cd2+ blocks voltage-gated Ca2+ entry but actually permeates TRPV1 sufficiently well to induce a major increase in Fura-2 fluorescence.
Gene_expression (channels) of Cd2
15) Confidence 0.21 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.27 Pain Relevance 0.29
This study aimed to develop immunohistochemical staining techniques to investigate the distribution and sequence of expression of both leukocyte [lymphocyte function associated antigen 1 (LFA-1)] and endothelial [intracellular adhesion molecule 1 (ICAM-1)] adhesion molecules in the mucosa after treatment with nonsteroidal anti-inflammatory drugs (NSAIDs).
Spec (investigate) Gene_expression (expression) of LFA-1 in leukocyte associated with inflammation, cinod and adhesions
16) Confidence 0.20 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7513960 Disease Relevance 0.55 Pain Relevance 0.29
CD2 and CD3 expression were normal, and the proportions of CD4, CD8 and CD45RO and CD45RA subsets were also unaffected by disease.
Gene_expression (expression) of CD2 associated with disease
17) Confidence 0.18 Published 1995 Journal Eur. J. Immunol. Section Abstract Doc Link 7614981 Disease Relevance 0.44 Pain Relevance 0.27
In adult male Sprague-Dawley rats maintained under propofol anesthesia, microinjection bilaterally into the NTS of OX-A or OX-B evoked bi-directional cardiovascular effects in a dose-dependent manner.
Gene_expression (microinjection) of OX-B associated with anesthesia
18) Confidence 0.18 Published 2007 Journal Neuroscience Section Abstract Doc Link 17916408 Disease Relevance 0 Pain Relevance 0.22
Treatment with mycophenolate mofetil reduces rheumatoid factor titres, immunoglobulin (IgG, IgM, and IgA) levels, and the total number of T cells (CD2) in RA patient peripheral blood; in addition, lymphocyte mitogen responses are inhibited and delayed hypersensitivity skin test reactivity is decreased.
Gene_expression (titres) of CD2 in lymphocyte associated with hypersensitivity and rheumatoid arthritis
19) Confidence 0.17 Published 1993 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 8324935 Disease Relevance 1.10 Pain Relevance 0.32
Four minor criteria include the presence of elevated serum alpha-tryptase levels > 20 ng/mL, the expression of CD2 and CD25 surface markers in c-kit-positive mast cells from bone marrow or other organs, the presence of a c-kit mutations on bone marrow and/or other tissues mast cells, and the presence of > 25% abnormal spindle-shaped mast cells in bone marrow and/or tissues.
Gene_expression (expression) of CD2 in mast cells
20) Confidence 0.15 Published 2004 Journal Allergy Asthma Proc Section Abstract Doc Link 15055560 Disease Relevance 1.59 Pain Relevance 0.10

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