INT118179

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.40
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv5) transmembrane transport (Trpv5)
Trpv5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 10 99.58 Very High Very High Very High
antagonist 2 99.24 Very High Very High Very High
intrathecal 2 96.96 Very High Very High Very High
Spinal cord 4 93.84 High High
Thermal hyperalgesia 2 87.92 High High
member 8 3 86.04 High High
allodynia 2 85.04 High High
Peripheral nerve injury 4 84.48 Quite High
Neuropathic pain 8 83.28 Quite High
Central nervous system 2 78.64 Quite High
Disease Link Frequency Relevance Heat
Injury 10 99.58 Very High Very High Very High
Hyperalgesia 2 87.92 High High
Diabetic Nephropathy 4 86.20 High High
Neuropathic Pain 10 85.04 High High
Nervous System Injury 4 84.48 Quite High
Nociception 2 80.64 Quite High
Osteoporosis 2 66.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPV6, TRPV5, and calbindin-D9k mRNA levels were also upregulated, resulting in prevention of the reduction in lumbar BMD.
Positive_regulation (upregulated) of TRPV5
1) Confidence 0.68 Published 2006 Journal J. Bone Miner. Metab. Section Abstract Doc Link 16816923 Disease Relevance 0.12 Pain Relevance 0.09
Importantly, inactivation of the EF-hand pair reduced the TRPV5-mediated Ca(2+) current and increased the TRPV5 sensitivity to intracellular Ca(2+), accelerating the feedback inhibition of the channel.
Positive_regulation (increased) of TRPV5
2) Confidence 0.50 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15100231 Disease Relevance 0 Pain Relevance 0.11
A non-selective N-methyl-d-aspartate receptor antagonist, MK801, significantly attenuated the increase of tCaMKII and phosphorylated CaMKII.
Positive_regulation (increase) of tCaMKII associated with antagonist
3) Confidence 0.03 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15932604 Disease Relevance 1.15 Pain Relevance 0.92
The immunoreactivity of phosphorylated CaMKII showed an increase from 1 day after CCI, which preceded the up-regulation of tCaMKII.
Positive_regulation (up-regulation) of tCaMKII associated with eae
4) Confidence 0.03 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15932604 Disease Relevance 1.14 Pain Relevance 0.85

General Comments

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