INT11824

Context Info Confidence 0.57 First Reported 1992 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.39 Pain Relevance 0.53

small molecule metabolic process (GGT1) plasma membrane (GGT1) transferase activity, transferring acyl groups (GGT1) cellular amino acid metabolic process (GGT1)

GGT1 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 10 99.34 anesthesia 1 89.24 Bile 3 80.76 addiction 5 78.88 antagonist 1 31.28 Opioid 1 30.84 Angina 1 5.00

Disease Link Frequency Relevance Heat Exfoliation Syndrome 69 96.64 Intrahepatic Cholestasis 3 88.40 Cirrhosis 1 86.72 Gallstones 1 81.76 Bile Duct Neoplasms 1 81.24 Pathologic Constriction 1 79.00 Alcohol Addiction 6 75.00 Extrahepatic Cholestasis 1 73.12 Glaucoma 52 67.56 Genetic Predisposition To Disease 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Of 70 patients (35 placebo; 35 naltrexone) who met an a priori definition of compliance (80% tablet consumption, attendance at all follow-up appointments), those allocated to naltrexone reported consuming half the amount of alcohol (P: < 0.05), had greater median reduction in serum GGT activity (P: < 0.05), and greater reduction in alcohol craving (OCDS total score: P: < 0.05; Obsessive subscale score: P: < 0.05), compared to patients in the placebo group.

Negative_regulation (reduction) of GGT associated with alcohol

1) Confidence 0.57 Published 2000 Journal Alcohol Alcohol. Section Abstract Doc Link 11093966 Disease Relevance 0.07 Pain Relevance 0.32

The hepatobiliary enzymes (ALP, GGT, and AST) were increased at stage A and significantly decreased at stage B.

Negative_regulation (decreased) of GGT

2) Confidence 0.41 Published 1992 Journal Clin Investig Section Abstract Doc Link 1600331 Disease Relevance 0.62 Pain Relevance 0.21

When the combined effects of these three SNPs were tabulated, the GGT haplotype was significantly overrepresented while the two haplotypes of GAC and TGC were significantly underrepresented in the XFS patients (Table 5).

Negative_regulation (overrepresented) of GGT associated with exfoliation syndrome

3) Confidence 0.41 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2268854 Disease Relevance 0.69 Pain Relevance 0

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