INT118482

Context Info Confidence 0.31 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.83 Pain Relevance 0.21

mitochondrion (Fasn) lyase activity (Fasn) oxidoreductase activity (Fasn) Golgi apparatus (Fasn) biosynthetic process (Fasn) plasma membrane (Fasn)

Anatomy Link Frequency liver 1 apoptotic cells 1 Fasn (Mus musculus)

Pain Link Frequency Relevance Heat Pain 30 74.40 Inflammation 30 58.16 Paracetamol 3 50.00 cytokine 6 25.68 agonist 9 5.00 Kinase C 6 5.00 Inflammatory response 6 5.00 Cholecystokinin 3 5.00 alcohol 3 5.00 Crohn's disease 3 5.00

Disease Link Frequency Relevance Heat Mental Disorders 4 79.20 Pain 12 74.40 Disease 11 72.24 Adrenoleukodystrophy 1 71.60 Targeted Disruption 17 69.28 Injury 4 68.84 INFLAMMATION 34 58.16 Cancer 7 51.52 Arrhythmia Under Development 1 50.32 Hypolipidemia 1 50.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: The activities of serum ALT and AST were significantly decreased and both necrosis and inflammatory infiltration were improved in the mice treated with sHSS 3.0 and 1.5 mg.kg-1. sHSS (3.0 mg.kg-1) prevented the ultrastructural changes of hepatocytes caused by AAP, decreased the percentage of apoptotic cells, and downregulated the expression level of Fas mRNA.

Negative_regulation (downregulated) of Fas mRNA in apoptotic cells

1) Confidence 0.31 Published 2004 Journal Yao Xue Xue Bao Section Body Doc Link 15127575 Disease Relevance 0.07 Pain Relevance 0

During the last 50 to 100 years the typical Western diet has contained increasing amounts of n-6 FAs and decreasing amounts of n-3 FAs [6].

Negative_regulation (decreasing) of FAs

2) Confidence 0.25 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1471788 Disease Relevance 0.64 Pain Relevance 0.18

Experiments with liver-specific inactivation of fatty-acid synthase (FAS) suggest that products of FAS serve as endogenous activators of PPAR?

Negative_regulation (inactivation) of fatty-acid synthase in liver

3) Confidence 0.10 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.13 Pain Relevance 0.03

General Comments

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