INT11919

Context Info Confidence 0.10 First Reported 1991 Last Reported 2007 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 4.97 Pain Relevance 0.77

plasma membrane (KRT1) cytoskeleton (KRT1)

Anatomy Link Frequency neuron 2 smooth muscle 1 filaments 1 KRT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Serotonin 2 98.16 Neuropeptide 2 97.72 Somatostatin 2 96.64 Calcitonin gene-related peptide 8 89.76 cva 7 86.48 Enkephalin 1 78.56 palliative 4 73.00 headache 8 62.60 endometriosis 1 18.64 abdominal pain 1 11.08

Disease Link Frequency Relevance Heat Cancer 47 100.00 Cystitis 1 97.32 Meningioma 3 96.04 Alzheimer's Dementia 7 94.80 Polycystic Kidney Disease 18 93.72 Necrosis 4 92.52 Cerebral Aneurysm 12 91.56 Chronic Renal Failure 27 90.44 Merkel Cell Carcinoma 26 88.76 Rhinitis 1 88.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to positive carcinoembryonic antigen and cytokeratin, the argyrophilic cancer cells were immunoreactive for neuron-specific enolase, chromogranin A, serotonin, neuropeptide Y, glicentin, somatostatin, neurotensin and calcitonin.

Regulation (immunoreactive) of cytokeratin in neuron associated with cancer, somatostatin, neuropeptide and serotonin

1) Confidence 0.10 Published 1991 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 1942551 Disease Relevance 1.19 Pain Relevance 0.22

The argyrophilic tumor cells with occasional mitoses and focal venous involvement predominantly showed immunoreactivity of cytokeratin, neuron-specific enolase, cystatin C, chromogranin A, calcitonin and neuropeptide Y (NPY).

Regulation (immunoreactivity) of cytokeratin in neuron associated with cancer and neuropeptide

2) Confidence 0.08 Published 1992 Journal Acta Pathol. Jpn. Section Abstract Doc Link 1609616 Disease Relevance 0.86 Pain Relevance 0.35

Immunohistochemistry revealed strong positivity for cytokeratin 20 (Figure 4c) and neurofilament (not shown) in the characteristic dot-like pattern and a weak expression of chromogranin A (Figure 4d).

Regulation (positivity) of cytokeratin

3) Confidence 0.06 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1208966 Disease Relevance 0.38 Pain Relevance 0.09

We note that except for low values of k1 and b, P5 performance is relatively insensitive to parameter settings (more on this below).

Neg (except) Regulation (values) of k1

4) Confidence 0.04 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC2212667 Disease Relevance 0 Pain Relevance 0

The association of intermediate filaments with desmosomal junctions in meningiomas, arachnoid membrane, and arachnoid granulations was first reported by Kartenbeck et al. and Schwecheimer et al. [10,14], who demonstrated that desmosomal plaques anchored vimentin filaments, while cytokeratin immunoreactivity within these tissues was not found.

Regulation (immunoreactivity) of cytokeratin in filaments associated with meningioma

5) Confidence 0.04 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.10 Pain Relevance 0

Immunohistochemistry showed that the neoplastic cells were positive for smooth muscle actin and for h-caldesmon and negative for CD34, calponin, FVIII-associated antigen, S100, EMA and cytokeratin AE1 AE3.

Regulation (positive) of cytokeratin AE1 AE3 in smooth muscle

6) Confidence 0.03 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2221972 Disease Relevance 0.86 Pain Relevance 0.04

The presence of L3287del mutation in five affected members (II-1, II-2, III-2, III-4, and III-6) but its absence in eight unaffected members of PK002 family were demonstrated (Figure 5D).

Regulation (affected) of II-1

7) Confidence 0.00 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.33 Pain Relevance 0

Obvious mobility shifts in the MRF-SSCP analysis were observed in SI-7 PCR product from PKD1 cDNA of an affected member (II-1) of this family when compared with the normal counterparts (Figure 5A).

Regulation (affected) of II-1

8) Confidence 0.00 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.58 Pain Relevance 0

Mutation segregation analysis by Eco0109 I digestion of amplified genomic DNA samples in the family PK039 showed that three affected members (I-1, I-2, and II-1) carried the mutation while a non-affected person (II-2) did not (Figure 4C).

Regulation (affected) of II-1

9) Confidence 0.00 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC356914 Disease Relevance 0.68 Pain Relevance 0.06

General Comments

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