INT119330

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.96
Pain Relevance 3.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Calcrl) endosome (Calcrl) endoplasmic reticulum (Calcrl)
plasma membrane (Calcrl) lysosome (Calcrl) signal transducer activity (Calcrl)
Calcrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 256 100.00 Very High Very High Very High
Spinal cord 12 95.84 Very High Very High Very High
Nucleus accumbens 4 92.40 High High
Migraine 7 90.36 High High
headache 8 89.60 High High
nMDA receptor 38 84.08 Quite High
trigeminal ganglion 3 81.60 Quite High
spinal inflammation 3 77.28 Quite High
Inflammation 7 68.24 Quite High
antagonist 10 67.44 Quite High
Disease Link Frequency Relevance Heat
Lung Injury 4 97.20 Very High Very High Very High
Frailty 2 96.12 Very High Very High Very High
Nociception 14 91.96 High High
Headache 15 90.36 High High
Ganglion Cysts 3 80.72 Quite High
Low Back Pain 3 77.28 Quite High
Paralysis 20 75.00 Quite High
INFLAMMATION 5 68.24 Quite High
Pain 101 60.80 Quite High
Disease 5 59.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the distribution of CGRP receptors in the rat trigeminovascular system we used antibodies recognizing two components of the CGRP receptor, the calcitonin receptor-like receptor (CLR) and the receptor activity-modifying protein 1 (RAMP1).
CGRP receptor Binding (recognizing) of associated with calcitonin gene-related peptide
1) Confidence 0.37 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18186028 Disease Relevance 0.35 Pain Relevance 0.63
To study the distribution of CGRP receptors in the rat trigeminovascular system we used antibodies recognizing two components of the CGRP receptor, the calcitonin receptor-like receptor (CLR) and the receptor activity-modifying protein 1 (RAMP1).
calcitonin receptor-like receptor Binding (recognizing) of associated with calcitonin gene-related peptide
2) Confidence 0.37 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18186028 Disease Relevance 0.35 Pain Relevance 0.64
To study the distribution of CGRP receptors in the rat trigeminovascular system we used antibodies recognizing two components of the CGRP receptor, the calcitonin receptor-like receptor (CLR) and the receptor activity-modifying protein 1 (RAMP1).
CLR Binding (recognizing) of associated with calcitonin gene-related peptide
3) Confidence 0.37 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18186028 Disease Relevance 0.35 Pain Relevance 0.66
Functional CGRP1 receptors are formed by a heterodimeric complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) [69,70].
CRLR Binding (complex) of
4) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.11 Pain Relevance 0.69
Coexpression of RAMP1 and CRLR resulted in functional CGRP1 receptors; the complex of RAMP2 or RAMP3 and CRLR created functional adrenomedullin receptor.
CRLR Binding (complex) of
5) Confidence 0.35 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15193773 Disease Relevance 0.12 Pain Relevance 0.30
The link between acute physiological changes and improved outcomes associated with CLR remain to be determined.



CLR Binding (associated) of
6) Confidence 0.24 Published 2001 Journal Crit Care Section Body Doc Link PMC30713 Disease Relevance 0.06 Pain Relevance 0
Functional CGRP1 receptors are formed by a heterodimeric complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) [69,70].
calcitonin receptor-like receptor Binding (complex) of
7) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.11 Pain Relevance 0.69
The link between acute physiological changes and improved outcomes associated with CLR remain to be determined.



CLR Binding (associated) of
8) Confidence 0.18 Published 2001 Journal Crit Care Section Abstract Doc Link PMC30713 Disease Relevance 0.27 Pain Relevance 0.05
The wild-type B*2704 and N97D mutants were associated with TAP, CNX and CLR, although HC10 forms of mutant N97D interact more weakly with TAP.
CLR Binding (associated) of
9) Confidence 0.02 Published 2006 Journal Int. Immunol. Section Abstract Doc Link 16361312 Disease Relevance 0.24 Pain Relevance 0.18

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