INT11939

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 138
Total Number 143
Disease Relevance 87.46
Pain Relevance 41.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophage 7
plasma 5
neutrophil 4
liver 3
myocardium 2
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2269 100.00 Very High Very High Very High
cytokine 2197 100.00 Very High Very High Very High
rheumatoid arthritis 710 100.00 Very High Very High Very High
chemokine 376 100.00 Very High Very High Very High
antagonist 125 100.00 Very High Very High Very High
Inflammatory mediators 111 100.00 Very High Very High Very High
Inflammatory marker 40 100.00 Very High Very High Very High
Nerve growth factor 40 100.00 Very High Very High Very High
cINOD 59 99.72 Very High Very High Very High
Paracetamol 33 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2495 100.00 Very High Very High Very High
Rheumatoid Arthritis 964 100.00 Very High Very High Very High
Disease 913 100.00 Very High Very High Very High
Cancer 343 100.00 Very High Very High Very High
Asthma 229 100.00 Very High Very High Very High
Targeted Disruption 172 100.00 Very High Very High Very High
Necrosis 153 100.00 Very High Very High Very High
Nociception 15 100.00 Very High Very High Very High
Parkinson's Disease 15 100.00 Very High Very High Very High
Injury 568 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of the nonsteroidal anti-inflammatory drug indomethacin decreased the levels of IL-6 by 75% to 80%.
Negative_regulation (decreased) of IL-6 associated with inflammation and cinod
1) Confidence 0.59 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.53 Pain Relevance 0.23
It is likely that this reduction of IL-6 protein by U50,488 treatment is attributed to decreases in IL-6 mRNA.
Negative_regulation (decreases) of IL-6 mRNA
2) Confidence 0.59 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16644488 Disease Relevance 0.22 Pain Relevance 0.77
Inhibitors of IL-6 or of its signal transducing receptor gp130 constitute a novel class of anti-inflammatory drugs, which raise great hopes for improved treatments of painful inflammatory diseases such as rheumatoid arthritis.
Negative_regulation (Inhibitors) of IL-6 associated with pain, inflammation, rheumatoid arthritis, cinod and disease
3) Confidence 0.55 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19864560 Disease Relevance 0.69 Pain Relevance 0.63
In addition, decreases in IL-6 within 48 h were associated with uncomplicated outcomes, whereas increases in IL-6 were associated with complications.
Negative_regulation (decreases) of IL-6
4) Confidence 0.53 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.67 Pain Relevance 0.03
Thus, attenuation of leukocyte recruitment by EPA may result in the decreased production levels of IL-6 and MCP-1 in the retina and choroid.
Negative_regulation (decreased) of IL-6 in retina
5) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.14 Pain Relevance 0.41
Experiments performed in vitro showed that pristane-elicited macrophages secreted low levels of IL-6 constitutively and high levels of IL-6 in the presence of lipopolysaccharide.
Negative_regulation (levels) of IL-6 in elicited macrophages
6) Confidence 0.43 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.47 Pain Relevance 0.20
The results reported here demonstrate that IL-6 deficiency attenuates the development of hypoxic PH in mice.
Negative_regulation (deficiency) of IL-6 associated with primary pulmonary hypertension and hypoxia
7) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.06 Pain Relevance 0.03
We used mice with targeted disruption of the IL-6 gene to investigate PH development and lung macrophage infiltration during exposure to chronic hypoxia [25].


Negative_regulation (disruption) of IL-6 gene in macrophage associated with targeted disruption, primary pulmonary hypertension and hypoxia
8) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.31 Pain Relevance 0.03
The purpose of this study was to investigate whether IL-6 deficiency affected the development of pulmonary vascular remodeling and PH during chronic hypoxia.
Spec (whether) Negative_regulation (deficiency) of IL-6 associated with primary pulmonary hypertension and hypoxia
9) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.49 Pain Relevance 0.03
1,5-Benzodiazepine tricyclic derivatives exerting anti-inflammatory effects in mice by inhibiting interleukin-6 and prostaglandinE(2)production.
Negative_regulation (inhibiting) of interleukin-6 associated with inflammation and analgesic
10) Confidence 0.43 Published 2001 Journal Pharmacol. Res. Section Title Doc Link 11394936 Disease Relevance 0.50 Pain Relevance 0.42
Effects of IL-6 and IL-6 deficiency on Nox2 activity: oximetry and EPR spectroscopy in synaptosomes from IL-6-treated and IL-6-/- mice
Negative_regulation (deficiency) of IL-6
11) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.09 Pain Relevance 0
IL-6 deficiency, or reduction of neuronal superoxide production, ameliorates impaired spatial learning in normal aging mice
Negative_regulation (deficiency) of IL-6 in neuronal associated with aging
12) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.16 Pain Relevance 0.12
Effects of IL-6 and IL-6 deficiency on Nox2 activity: oximetry and EPR spectroscopy in synaptosomes from IL-6-treated and IL-6-/- mice
Negative_regulation (deficiency) of IL-6
13) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.09 Pain Relevance 0
Both IL-6 and prostaglandin E2 production were inhibited by addition of indomethacin to macrophage cultures in vitro.
Negative_regulation (inhibited) of IL-6 in macrophage
14) Confidence 0.43 Published 1992 Journal Blood Section Abstract Doc Link 1611085 Disease Relevance 0.41 Pain Relevance 0.17
We interpreted the stimulation induced by sIL-6R alone as an autocrine effect of IL-6 produced by PA-SMCs, an observation also made by others using SMCs from the human aorta [35].
Negative_regulation (effect) of IL-6 in aorta
15) Confidence 0.43 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.37 Pain Relevance 0.06
The effect of compounds A, B and C on leukocyte recruitment was paralleled by a significant inhibition of interleukin-6 and prostaglandin E(2)production in the exudate, similarly to indomethacin, and by a partial reduction of vascular permeability.
Negative_regulation (inhibition) of interleukin-6 in leukocyte
16) Confidence 0.43 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11394936 Disease Relevance 0.28 Pain Relevance 0.24
It is likely that this reduction of IL-6 protein by U50,488 treatment is attributed to decreases in IL-6 mRNA.
Negative_regulation (reduction) of IL-6
17) Confidence 0.43 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16644488 Disease Relevance 0.23 Pain Relevance 0.77
0.25); whereas the IL-6 deficient mice did (F(3,27)?
Negative_regulation (deficient) of IL-6
18) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.08 Pain Relevance 0.08
Sympathetic invasion of the fiber tract and cell layer of the DRG, and the formation of pericellular axonal baskets were all significantly reduced in the IL-6 knockout mice compared to the control strain.
Negative_regulation (reduced) of IL-6 in DRG associated with targeted disruption, dorsal root ganglion and sprains and strains
19) Confidence 0.42 Published 1998 Journal Pain Section Abstract Doc Link 9839821 Disease Relevance 1.11 Pain Relevance 0.68
Indeed, mice lacking IL-6 (IL-6-/-) were more susceptible than were WT mice to APAP-induced liver injury.
Negative_regulation (lacking) of IL-6 in liver associated with paracetamol and injury
20) Confidence 0.42 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12705907 Disease Relevance 0.59 Pain Relevance 0.48

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