INT119422

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.09
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6)
cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)
Anatomy Link Frequency
chondrocytes 2
brains 2
MAP2K6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 103 99.60 Very High Very High Very High
opiate 7 97.08 Very High Very High Very High
Morphine 2 92.24 High High
addiction 3 90.28 High High
metalloproteinase 8 88.48 High High
cINOD 5 83.48 Quite High
opioid receptor 1 67.92 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 104 99.60 Very High Very High Very High
Targeted Disruption 3 95.92 Very High Very High Very High
Urological Neuroanatomy 3 95.08 Very High Very High Very High
Cancer 3 90.60 High High
Opiate Addiction 3 90.28 High High
Colon Cancer 2 85.96 High High
INFLAMMATION 16 75.00 Quite High
Congenital Anomalies 1 71.28 Quite High
Arthritis 9 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher concentrations produced no additional suppression of phosphorylation of either MKK3 or MKK6 in human OA chondrocytes.


Neg (no) Negative_regulation (suppression) of Phosphorylation (phosphorylation) of MKK6 in chondrocytes associated with osteoarthritis
1) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.07 Pain Relevance 0.45
MEK inhibitors, PD98059 and U-0126, which inhibited ERK phosphorylation were shown to elevate 15-PGDH levels very significantly.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of MEK
2) Confidence 0.09 Published 2009 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 19501039 Disease Relevance 0.54 Pain Relevance 0.45
Notably, pronounced downregulations of phosphorylated MEK (85%) and ERK1/2 (pERK1: 81%; pERK2: 80%) were quantitated in brains of opiate addicts.
Negative_regulation (downregulations) of Phosphorylation (phosphorylated) of MEK in brains associated with opiate
3) Confidence 0.05 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15198681 Disease Relevance 0.47 Pain Relevance 0.86

General Comments

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