INT119429

Context Info Confidence 0.29 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.17 Pain Relevance 0.63

cell differentiation (Stmn1) cytosol (Stmn1) cytoskeleton (Stmn1) intracellular (Stmn1) cytoplasm (Stmn1)

Anatomy Link Frequency hypothalamus 1 Stmn1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 46 96.84 Morphine 5 88.12 agonist 36 81.68 Glutamate 9 5.00 Neurotransmitter 7 5.00 Central nervous system 6 5.00 gABA 4 5.00 Paracetamol 1 5.00 Somatostatin 1 5.00 GABAergic 1 5.00

Disease Link Frequency Relevance Heat Aids-related Complex 1 97.62 Repression 1 70.72 Disease 8 5.00 Death 4 5.00 Neurological Disease 2 5.00 Schizophrenia 2 5.00 Generalized Anxiety Disorder 2 5.00 Parkinson's Disease 1 5.00 Stress Incontinence 1 5.00 Apoptosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Glial fibrillary acidic protein (Gfap) and activity-regulated cytoskeleton-associated protein (Arc) mRNA were upregulated, while growth associated protein (Gap43), clathrin heavy chain (Cltc), alpha-tubulin, Tau, and stathmin were downregulated.

Negative_regulation (downregulated) of stathmin associated with aids-related complex

1) Confidence 0.29 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.10 Pain Relevance 0.38

The decreases in Apo-14, stathmin 1, microtubule-associated protein tau, along with an increase in microtubule-associated protein 1A and spectrin alpha 2 (Table 1) suggests that DA may also have remodelling effects on the cytoskeleton of cells in the goldfish hypothalamus.

Negative_regulation (decreases) of stathmin 1 in hypothalamus associated with dopamine

2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924890 Disease Relevance 0.07 Pain Relevance 0.25

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