INT119514

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.61
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Pno1) RNA binding (Pno1) nucleus (Pno1)
biological_process (Pno1)
Anatomy Link Frequency
epithelial cells 1
Pno1 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 1 100.00 Very High Very High Very High
antagonist 3 99.74 Very High Very High Very High
gABA 6 98.76 Very High Very High Very High
Neurotransmitter 1 98.08 Very High Very High Very High
Dismenorea 28 97.32 Very High Very High Very High
agonist 2 93.92 High High
tetrodotoxin 1 93.12 High High
anesthesia 4 92.24 High High
isoflurane 2 88.28 High High
Potency 1 76.00 Quite High
Disease Link Frequency Relevance Heat
Pneumonia 31 100.00 Very High Very High Very High
Dysmenorrhea 28 97.32 Very High Very High Very High
Disease 2 96.80 Very High Very High Very High
Severe Combined Immunodeficiency 2 28.20 Quite Low
Sepsis 27 5.00 Very Low Very Low Very Low
Papillomavirus Infection 8 5.00 Very Low Very Low Very Low
Bacterial Pneumonia 6 5.00 Very Low Very Low Very Low
Adult Respiratory Distress Syndrome 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Lung Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects on phenotypes of arousal support the conclusion that GABA(A) receptors in the PnO promote wakefulness and suggest that increasing GABAergic transmission in the PnO may be one mechanism underlying the phenomenon of paradoxical behavioral activation by some benzodiazepines.
Positive_regulation (increasing) of PnO associated with gaba and gabaergic
1) Confidence 0.41 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20844126 Disease Relevance 0 Pain Relevance 0.45
The muscarinic antagonist scopolamine increased ACh release in the PnO by 21% (3 nM), 48% (10 nM), 56% (30 nM), and 104% (100 nM).
Positive_regulation (increased) of PnO associated with antagonist
2) Confidence 0.24 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207318 Disease Relevance 0 Pain Relevance 0.36
Oestrogen-induced epithelial-mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis.
Positive_regulation (induced) of epithelial-mesenchymal transition in epithelial cells associated with dismenorea
3) Confidence 0.06 Published 2010 Journal J. Pathol. Section Title Doc Link 20814901 Disease Relevance 0.85 Pain Relevance 0.75
Epithelial-mesenchymal transition (EMT) endows cells with migratory and invasive properties and can be induced by oestrogen.
Positive_regulation (induced) of Epithelial-mesenchymal transition
4) Confidence 0.06 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20814901 Disease Relevance 0.66 Pain Relevance 0.56
However when we calculated the pulmonary vascular resistance index (PVRI), there was a statistically significant increase in PVRI in all pneumonia groups (PCON, PNO, and PNANO) compared to the surgical controls for 3 hr after bacterial instillation (p<0.05).
Positive_regulation (increase) of PNO associated with pneumonia
5) Confidence 0.01 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721948 Disease Relevance 0.10 Pain Relevance 0

General Comments

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