INT119523

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 26.47
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EDNRB) signal transducer activity (EDNRB)
Anatomy Link Frequency
endothelial cells 4
smooth muscle cells 4
smooth muscle 3
fibroblasts 2
sensory neurons 1
EDNRB (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 667 100.00 Very High Very High Very High
analgesia 17 100.00 Very High Very High Very High
nociceptor 16 99.62 Very High Very High Very High
cva 19 99.30 Very High Very High Very High
Pain 60 98.94 Very High Very High Very High
cytokine 27 98.16 Very High Very High Very High
Analgesic 1 98.16 Very High Very High Very High
Inflammation 36 98.04 Very High Very High Very High
metalloproteinase 70 96.08 Very High Very High Very High
Cancer pain 6 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Breast Cancer 68 99.84 Very High Very High Very High
Skin Cancer 174 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 244 99.64 Very High Very High Very High
Pulmonary Hypertension 877 99.60 Very High Very High Very High
Cancer 667 99.32 Very High Very High Very High
Cv General 3 Under Development 14 99.30 Very High Very High Very High
Pain 55 98.94 Very High Very High Very High
Hyperoxia 110 98.68 Very High Very High Very High
Nociception 11 98.38 Very High Very High Very High
Disease 207 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antagonism of the ETA receptors inhibits the ET-1-induced contraction in parenchymal strips, whereas this treatment is ineffective in isolated bronchi [38], indicating that the antagonist ETA receptors are expressed in greater density in the lung parenchyma, while the ETB receptors are expressed more markedly in the airways.
Gene_expression (expressed) of ETB in parenchyma associated with antagonist
1) Confidence 0.75 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.38 Pain Relevance 0.12
Endothelin-1 receptor subtype B (ETB) is expressed in smooth muscle and endothelial cells.19 Activation of endothelial ETB mediates clearance of endothelin-1 and vasodilatation by nitric oxide and prostacyclin release.16 Because of these effects ETB activation is theoretically desirable in PAH.
Gene_expression (expressed) of ETB in endothelial cells associated with pulmonary hypertension and increased venous pressure under development
2) Confidence 0.75 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940744 Disease Relevance 1.00 Pain Relevance 0.10
Nociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats.
Gene_expression (acting) of ETB associated with analgesic
3) Confidence 0.65 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16024732 Disease Relevance 0.58 Pain Relevance 0.84
Two groups of animals kept in room air (group C, n = 8) or were exposed to hyperoxia for 60 h (group Hox, n = 10) were not subjected to ET-1 receptor blockade, dual ETA/ETB-receptor blocker TEZ was administered continuously for 6 days via an intraperitoneal pump (10 mg/kg/day) to two other groups of mice, likewise kept in room air (group CT, n = 6) or exposed to hyperoxia for 60 h (group HoxT, n = 7).
Gene_expression (blockade) of ETB associated with hyperoxia
4) Confidence 0.65 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.59 Pain Relevance 0
ET-1 acts on two G protein-coupled receptors termed ETA and ETB (Arai et al 1990; Sakurai et al 1990).
Gene_expression (termed) of ETB
5) Confidence 0.65 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605321 Disease Relevance 0.73 Pain Relevance 0.05
For these purposes we studied rat mesenteric arteries in which ETA- and ETB-receptors are expressed by several cell types[31], [32], [33].
Gene_expression (expressed) of ETB
6) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0.14 Pain Relevance 0.28
It has been demonstrated in both rat and monkey models of sub-arachnoid hemorrhage that increased smooth muscle cell ETB receptor expression induces vasospasm of cerebral vessels (Hino et al 1996; Hansen-Schwartz et al 2003).
Gene_expression (expression) of ETB in smooth muscle cell associated with cva and increased venous pressure under development
7) Confidence 0.57 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.63 Pain Relevance 0.08
The endothelin-B (ETB) receptor is expressed in primary and metastatic malignant melanoma, and increased expression of ETB correlates with tumor progression in malignant melanoma [15].
Gene_expression (expression) of ETB associated with cancer and skin cancer
8) Confidence 0.54 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2856553 Disease Relevance 0.93 Pain Relevance 0.04
The endothelin-B (ETB) receptor is expressed in primary and metastatic malignant melanoma, and increased expression of ETB correlates with tumor progression in malignant melanoma [15].
Gene_expression (expressed) of ETB associated with cancer and skin cancer
9) Confidence 0.47 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2856553 Disease Relevance 0.85 Pain Relevance 0.04
Endothelin receptor subtype A (ETA) is predominantly found in smooth muscle and also on fibroblasts, whereas receptor subtype B (ETB) is expressed on smooth muscle and endothelial cells.19 Endothelial ETB activation mediates clearance of endothelin-1 and vasodilatation by nitric oxide and prostacyclin release.18 Because of these effects ETB activation is theoretically desirable in PAH.
Gene_expression (expressed) of ETB in fibroblasts associated with pulmonary hypertension and increased venous pressure under development
10) Confidence 0.47 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.72 Pain Relevance 0.14
Here we show that in a murine osteolytic 2472 sarcoma model of bone cancer pain, the 2472 sarcoma cells express high levels of ET-1, but express low or undetectable levels of endothelin A (ETAR) or B (ETBR) receptors whereas a subpopulation of sensory neurons express the ETAR and non-myelinating Schwann cells express the ETBR.
Gene_expression (express) of ETBR in sensory neurons associated with sarcoma and cancer pain
11) Confidence 0.44 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207337 Disease Relevance 1.24 Pain Relevance 0.67
Langleben et al found that most PAH patients have intact endothelial ETB-mediated clearance, despite a reduced microvascular surface area from vascular remodeling, suggesting that increased expression of ETB is needed to maintain normal endothelin clearance (Langleben et al 2006).
Gene_expression (expression) of ETB associated with pulmonary hypertension
12) Confidence 0.44 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.45 Pain Relevance 0.13
Two studies have demonstrated increased pulmonary vascular smooth muscle expression of ETB in human PAH (Bauer et al 2002; Davie et al 2002).
Gene_expression (expression) of ETB in smooth muscle associated with pulmonary hypertension
13) Confidence 0.44 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.55 Pain Relevance 0.16
Increased expression of ETB in pulmonary vascular endothelial cells should enhance ET-1-mediated release of NO and prostacyclin while improving clearance of ET-1 from the circulation (de Nucci et al 1988), whereas increased expression of ETB in pulmonary vascular smooth muscle cells would be expected to increase vasoconstriction and perhaps worsen medial thickening.
Gene_expression (expression) of ETB in smooth muscle cells associated with increased venous pressure under development
14) Confidence 0.44 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.55 Pain Relevance 0.12
Increased expression of ETB in pulmonary vascular endothelial cells should enhance ET-1-mediated release of NO and prostacyclin while improving clearance of ET-1 from the circulation (de Nucci et al 1988), whereas increased expression of ETB in pulmonary vascular smooth muscle cells would be expected to increase vasoconstriction and perhaps worsen medial thickening.
Gene_expression (expression) of ETB in endothelial cells associated with increased venous pressure under development
15) Confidence 0.44 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.57 Pain Relevance 0.13
ETA mediates the vasoconstrictor effect of ET on vascular smooth muscle, whereas ETB is expressed primarily on vascular endothelial cells where it induces nitric oxide synthesis and acts to clear ET from the circulation.
Gene_expression (expressed) of ETB in endothelial cells
16) Confidence 0.44 Published 2008 Journal Drug design, development and therapy Section Abstract Doc Link PMC2761178 Disease Relevance 0.61 Pain Relevance 0.17
Transformed melanocytes express both ETAR and ETBR.
Gene_expression (express) of ETBR in melanocytes
17) Confidence 0.44 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.64 Pain Relevance 0.13
ET-1 and its receptors, ETAR and ETBR, are overexpressed in breast carcinomas.
Gene_expression (overexpressed) of ETBR associated with breast cancer
18) Confidence 0.44 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.54 Pain Relevance 0.10
Endothelin receptor subtype A (ETA) is predominantly found in smooth muscle and also on fibroblasts, whereas receptor subtype B (ETB) is expressed on smooth muscle and endothelial cells.19 Endothelial ETB activation mediates clearance of endothelin-1 and vasodilatation by nitric oxide and prostacyclin release.18 Because of these effects ETB activation is theoretically desirable in PAH.
Gene_expression (expressed) of ETB in fibroblasts associated with pulmonary hypertension and increased venous pressure under development
19) Confidence 0.41 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.72 Pain Relevance 0.15
Additionally, activation of ETBR pathway by ET-1 and ET-3 contributes to disruption of normal host-tumor interactions by downregulating the expression of E-cadherin and associated ?
Gene_expression (pathway) of ETBR associated with cancer
20) Confidence 0.38 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.00 Pain Relevance 0.07

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