INT119974

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.60
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY2) aging (P2RY2) plasma membrane (P2RY2)
embryo development (P2RY2) lysosome (P2RY2) signal transducer activity (P2RY2)
Anatomy Link Frequency
platelets 1
P2RY2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 24 100.00 Very High Very High Very High
interstitial cystitis 7 99.02 Very High Very High Very High
Pain 2 85.32 High High
adenocard 2 84.00 Quite High
Inflammation 8 75.84 Quite High
anesthesia 8 59.12 Quite High
agonist 13 51.52 Quite High
aspirin 7 25.00 Low Low
Angina 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 7 99.02 Very High Very High Very High
Wound Healing 92 92.40 High High
Injury 176 88.08 High High
Cataract 4 76.24 Quite High
INFLAMMATION 8 75.84 Quite High
Myocardial Infarction 3 25.00 Low Low
Cv General 3 Under Development 2 25.00 Low Low
Stroke 1 25.00 Low Low
Peripheral Arterial Disease 1 25.00 Low Low
Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that the P2Y2-R levels were significantly reduced to approximately 32% of control levels by P2Y2-R siRNA #2.
Negative_regulation (reduced) of P2Y2-R
1) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.06 Pain Relevance 0
The P2Y2-R reduction obtained with P2Y2-R siRNA #2 (Figure 2A) was greater than the observed reduction for P2Y2-R siRNA #1 (result not shown).
Negative_regulation (reduction) of P2Y2-R
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.15 Pain Relevance 0.04
and P2Y2-R specific reverse, 5?
Negative_regulation (reverse) of P2Y2-R
3) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.18 Pain Relevance 0.06
P2Y2-R down-regulation after siRNA transfection was determined by densitometric quantification of the P2Y2-R fluorescence signal in several images in four independent experiments.
Negative_regulation (down-regulation) of P2Y2-R
4) Confidence 0.38 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.63 Pain Relevance 0
Ticlopidine and clopidogrel both behave in vivo as specific antagonists of P2Y (12), one of the ADP receptors on platelets.
Negative_regulation (antagonists) of P2Y in platelets associated with antagonist
5) Confidence 0.06 Published 2005 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 15852221 Disease Relevance 0 Pain Relevance 0.28
In FIC cats, there is a marked reduction in P2X(1) and loss of P2Y(2) receptor staining.
Negative_regulation (loss) of P2Y associated with interstitial cystitis
6) Confidence 0.01 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15251862 Disease Relevance 0.58 Pain Relevance 0.66

General Comments

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