INT120046

Context Info Confidence 0.40 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.31 Pain Relevance 0.80

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl) vacuole (Ctsl) lysosome (Ctsl) cytoplasm (Ctsl)

Anatomy Link Frequency brains 2 vesicle 2 Ctsl (Mus musculus)

Pain Link Frequency Relevance Heat Dynorphin 7 100.00 Neuropeptide 4 94.48 analgesia 1 90.28 Opioid 1 88.12 Neurotransmitter 3 85.72 Enkephalin 1 70.32

Disease Link Frequency Relevance Heat Targeted Disruption 4 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cathepsin L knockout mouse brains showed extensive decreases in dynorphin A, dynorphin B, and alpha-neoendorphin that were reduced by 75%, 83%, and 90%, respectively, compared to controls.

Negative_regulation (reduced) of Localization (decreases) of Cathepsin L in brains associated with targeted disruption and dynorphin

1) Confidence 0.40 Published 2010 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 19837164 Disease Relevance 0.31 Pain Relevance 0.57

In this review, evidence for secretory vesicle cathepsin L and Arg/Lys aminopeptidase as a distinct proteolytic pathway for processing the prohormone proenkephalin is presented.

Negative_regulation (presented) of Localization (secretory) of cathepsin L in vesicle

2) Confidence 0.11 Published 2004 Journal Biol. Chem. Section Abstract Doc Link 15255178 Disease Relevance 0 Pain Relevance 0.23

General Comments

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