INT120056

Context Info Confidence 0.14 First Reported 2004 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 2.89 Pain Relevance 0.53

nucleus (NFIC) intracellular (NFIC) DNA binding (NFIC)

Anatomy Link Frequency thyroid 1 nerve 1 NFIC (Homo sapiens)

Pain Link Frequency Relevance Heat neuralgia 4 98.72 Neurobehavioral 10 95.48 depression 3 91.12 Quantitative sensory testing 20 76.84 Action potential 72 73.60 diabetic neuropathy 8 47.00 cva 2 10.00 headache 1 10.00 unmyelinated 12 5.00 Neuritis 4 5.00

Disease Link Frequency Relevance Heat Neuropathic Pain 96 99.30 Neuralgia 4 98.72 Nervous System Injury 44 97.24 Mycobacterium Infection 128 96.40 Dissociative Disorders 1 92.16 Depression 3 91.12 Diabetic Nephropathy 8 84.00 Diplopia 2 78.72 Brain Injury 58 68.96 Diabetes Mellitus 4 66.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hormone level evaluation revealed a low free thyroxine index and elevated prolactin levels, and normal levels of thyroid stimulating hormone, growth hormone, insulin-like growth factor type 1, and cortisol.

Gene_expression (levels) of factor type 1 in thyroid

1) Confidence 0.14 Published 2004 Journal Endocr Pract Section Body Doc Link 15256330 Disease Relevance 0.08 Pain Relevance 0

Although sensory and motor neuropathy was much more widespread than the NFI detected by MFT and VMT, these tests were still validated by the current results.

Gene_expression (detected) of NFI associated with neuropathic pain

2) Confidence 0.07 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2270341 Disease Relevance 0.74 Pain Relevance 0

Early detection and treatment of NFI is therefore seen as a top priority [11].

Gene_expression (detection) of NFI

3) Confidence 0.06 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2270341 Disease Relevance 0.87 Pain Relevance 0

Table 3 shows the relationship between duration of onset of clinically detectable NFI (MFT and VMT) and the duration of impairment as measured with neurophysiological tests.

Gene_expression (detectable) of NFI

4) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2270341 Disease Relevance 0 Pain Relevance 0.22

Even in patients with no clinical signs of reaction, no nerve tenderness, no clinically evident NFI (detectable by MFT or VMT), or symptoms of nerve pain, definite evidence of silent sensory and/or motor neuropathy was found (ulnar up to 26%, RC 50%, and sural 47%).

Gene_expression (detectable) of NFI in nerve associated with neuralgia and neuropathic pain

5) Confidence 0.05 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2270341 Disease Relevance 0.54 Pain Relevance 0.14

However, in subsequent studies the authors have compared the NFI (Johnston et al 2006) with functional measure such as FIM (Hall et al 1993).

Gene_expression (compared) of NFI

6) Confidence 0.05 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654797 Disease Relevance 0.66 Pain Relevance 0.18

General Comments

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