INT120088

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 37
Total Number 39
Disease Relevance 13.89
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp4) anatomical structure formation involved in morphogenesis (Bmp4) extracellular space (Bmp4)
growth (Bmp4) extracellular region (Bmp4) proteinaceous extracellular matrix (Bmp4)
Anatomy Link Frequency
bars 2
cartilage 2
glomerular capillary 1
hamstring muscles 1
bone marrow 1
Bmp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Snapping jaw 15 99.24 Very High Very High Very High
methotrexate 375 98.86 Very High Very High Very High
antagonist 32 98.36 Very High Very High Very High
Central nervous system 28 91.04 High High
cytokine 30 82.40 Quite High
Inflammation 165 82.00 Quite High
cINOD 130 80.32 Quite High
rheumatoid arthritis 45 72.88 Quite High
Osteoarthritis 40 72.32 Quite High
ischemia 13 60.28 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 87 99.88 Very High Very High Very High
Respiratory Failure 7 99.58 Very High Very High Very High
Heterotopic Ossification 846 99.52 Very High Very High Very High
Temporomandibular Joint Syndrome 15 99.24 Very High Very High Very High
Osteoporosis 54 98.88 Very High Very High Very High
Temporomandibular Joint Disorders 3 97.52 Very High Very High Very High
Congenital Anomalies 50 97.40 Very High Very High Very High
Calcification 25 97.20 Very High Very High Very High
Obesity 8 96.64 Very High Very High Very High
Atherosclerosis 7 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the ovariectomy group, the intensity of BMP-4 and Runx2 expression increased after ovariectomy.
Gene_expression (expression) of BMP-4
1) Confidence 0.73 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.08 Pain Relevance 0
Results: In the control group, BMP-4, Runx2, and BSP expressions showed no definite difference at any stage.
Gene_expression (expressions) of BMP-4
2) Confidence 0.73 Published 2007 Journal Oral Dis Section Body Doc Link 17305626 Disease Relevance 0.09 Pain Relevance 0
Alteration of BMP-4 and Runx2 expression patterns in mouse temporomandibular joint after ovariectomy.
Gene_expression (expression) of BMP-4 in temporomandibular joint associated with snapping jaw
3) Confidence 0.73 Published 2007 Journal Oral Dis Section Title Doc Link 17305626 Disease Relevance 0.47 Pain Relevance 0.45
BMP4 expression decreased almost significant at day 2, which correlated well with an increasing degree of morphological damage, increased proliferation, and loss of epithelial differentiation as measured by the decreased SI and likely TFF3 expression.
Gene_expression (expression) of BMP4
4) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.08 Pain Relevance 0.06
BMP4 protein expression showed a mild decrease in expression level at day 1 after DOX treatment (Figs. 4F, 7A).
Gene_expression (expression) of BMP4
5) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.10 Pain Relevance 0.03
The BMP4 protein expression of the control mice, analyzed by Western-blot technique (Fig. 4F), was set at 100% (A).
Spec (analyzed) Gene_expression (expression) of BMP4
6) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.07 Pain Relevance 0.05
After intestinal development, BMP4 is exclusively expressed in the intravillus and intracrypt mesenchymal cells, including those adjacent to the intestinal stem cells [8, 10].
Gene_expression (expressed) of BMP4 in intestinal stem cells
7) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.31 Pain Relevance 0.03
To examine the role of BMP4 signaling in intestinal homeostasis the expression of BMP4 was quantified.
Gene_expression (expression) of BMP4
8) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.08 Pain Relevance 0
During the regenerative phase, at day 7, BMP4 expression level was down-regulated again, which could be a response to the shortage in number of crypts, since a blockage of BMP4 has been shown to cause stem cells to divide, leading to newly formed crypts [8, 10].
Gene_expression (expression) of BMP4 in stem cells
9) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0
BMP4 was predominantly expressed in the intravillus mesenchym as shown by immunohistochemistry (Fig. 7B, C), both in control as in MTX-treated mice.Fig. 7Effect of high-dose DOX treatment on expression of the morphogen BMP4.
Gene_expression (expressed) of BMP4 associated with methotrexate
10) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.08 Pain Relevance 0.05
PCNA, Caspase-3, TCF4 and BMP4 protein expression levels were analyzed by Western-blot technique (F), the PCNA expression of control mice was set at 100% (G).
Spec (analyzed) Gene_expression (expression) of BMP4
11) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0.03
BMP4 is expressed in the intravillus and intracrypt mesenchymal cells [8, 10], inhibition of BMP signaling causes intestinal architectural abnormalities [8] and decreased differentiation as seen in tumorigenesis [27].
Gene_expression (expressed) of BMP4 in mesenchymal cells associated with congenital anomalies
12) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.10 Pain Relevance 0
At day 2, this decrease in BMP4 expression level progressed and was almost significant (P=0.05) in comparison to the control level.
Gene_expression (expression) of BMP4
13) Confidence 0.73 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.09 Pain Relevance 0.04
Expression of the morphogen BMP4 protein showed a decreasing trend at day 1, which was at the brink of significance (P=0.05) at day 2 in comparison to control expression.
Gene_expression (Expression) of morphogen BMP4 protein
14) Confidence 0.64 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.07 Pain Relevance 0.05
Here we show that there indeed might be a close relationship between BMP and Wnt pathways, because at day 1 when BMP4 expression is decreased, expression of TCF4, a Wnt effector, increased significantly, which correlated well with increased proliferation and inhibited epithelial differentiation.
Gene_expression (expression) of BMP4
15) Confidence 0.64 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.06 Pain Relevance 0
Thereafter, BMP4 day 2 but not to control.
Gene_expression (day) of BMP4
16) Confidence 0.63 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.09 Pain Relevance 0.04
The bars are expressed in mean + SEM

Effect of high-dose DOX treatment on expression of Bone morphogene 4 (BMP4)

Gene_expression (expression) of BMP4 in bars
17) Confidence 0.57 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.07 Pain Relevance 0
Furthermore, BMP expression was visualized with anti-BMP4 (1:100, R&D Systems, Abingdon, UK).
Gene_expression (expression) of BMP4
18) Confidence 0.57 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0 Pain Relevance 0
At day 3, the BMP4 expression showed an increasing trend.
Gene_expression (expression) of BMP4
19) Confidence 0.57 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.06 Pain Relevance 0.04
The localization of BMP4 expression did not change at day three (C) in comparison to control situation (B).
Gene_expression (expression) of BMP4
20) Confidence 0.57 Published 2007 Journal Dig Dis Sci Section Body Doc Link PMC1914222 Disease Relevance 0.11 Pain Relevance 0.04

General Comments

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