INT12034

Context Info Confidence 0.69 First Reported 1991 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 6 Total Number 7 Disease Relevance 3.25 Pain Relevance 1.33

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod) plasma membrane (Umod)

Anatomy Link Frequency urine 2 brain 1 Umod (Mus musculus)

Pain Link Frequency Relevance Heat interstitial cystitis 12 99.84 Inflammation 2 87.24 Dismenorea 1 83.28 Dysuria 1 60.64 anesthesia 2 58.00 Pain 1 56.84 antagonist 1 49.20 peripheral neuropathy 3 5.00 Spinal cord 2 5.00 Neuropathic pain 2 5.00

Disease Link Frequency Relevance Heat Interstitial Cystitis 12 99.84 Anaemia 1 94.80 Balkan Nephropathy 4 94.00 Glioma 2 89.20 Bacteriuria 1 87.96 INFLAMMATION 2 87.24 Uremia 3 82.48 Proteinuria 2 80.44 Cancer 2 78.64 Syndrome 1 75.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased urinary levels of Tamm-Horsfall glycoprotein suggest a systemic etiology of interstitial cystitis.

Positive_regulation (Increased) of Tamm-Horsfall glycoprotein associated with interstitial cystitis

1) Confidence 0.69 Published 1996 Journal J. Urol. Section Title Doc Link 8709369 Disease Relevance 0.10 Pain Relevance 0.19

Tamm-Horsfall protein may be increased in the urine.

Spec (may) Positive_regulation (increased) of Tamm-Horsfall protein in urine

2) Confidence 0.59 Published 1992 Journal Food Chem. Toxicol. Section Abstract Doc Link 1618441 Disease Relevance 1.55 Pain Relevance 0.12

The humoral response to Tamm-Horsfall protein in these patients suggests a role for Tamm-Horsfall protein in interstitial cystitis.

Positive_regulation (response) of Tamm-Horsfall protein associated with interstitial cystitis

3) Confidence 0.45 Published 1991 Journal J. Urol. Section Abstract Doc Link 1984095 Disease Relevance 0.56 Pain Relevance 0.44

The humoral response to Tamm-Horsfall protein in these patients suggests a role for Tamm-Horsfall protein in interstitial cystitis.

Positive_regulation (role) of Tamm-Horsfall protein associated with interstitial cystitis

4) Confidence 0.39 Published 1991 Journal J. Urol. Section Abstract Doc Link 1984095 Disease Relevance 0.55 Pain Relevance 0.44

Characterization of the Fabry-Rag mouse showed that urine uromodulin levels were significantly elevated.

Positive_regulation (elevated) of uromodulin in urine

5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0

We hypothesize that the high levels of E2 in pregnancy attenuate the increase in the conversion of P to THP in the brain and that the ratio of E2/P modulates the sedative effect of THP.

Positive_regulation (increase) of THP in brain

6) Confidence 0.35 Published 2004 Journal Brain Res. Section Abstract Doc Link 15312799 Disease Relevance 0.31 Pain Relevance 0.08

Although the levels of urinary beta 2-microglobulin and albumin after ESWL were significantly higher (p < 0.05) than the pre-ESWL levels in group 3, the changes in urinary albumin and Tamm-Horsfall protein were milder in group 3 than in group 1.

Positive_regulation (changes) of Tamm-Horsfall protein

7) Confidence 0.12 Published 1995 Journal J. Urol. Section Abstract Doc Link 7861490 Disease Relevance 0.19 Pain Relevance 0.06

General Comments

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