INT120400

Context Info Confidence 0.40 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.54 Pain Relevance 0.62

cytosol (MAP2K3) nucleoplasm (MAP2K3) signal transduction (MAP2K3)

MAP2K3 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 103 96.96 bradykinin 12 94.16 b2 receptor 3 75.00 cytokine 8 69.72 Inflammation 17 25.00 Pain 3 25.00 Arthritis 8 5.00 metalloproteinase 6 5.00 rheumatoid arthritis 4 5.00 Inflammatory stimuli 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 104 96.96 Stress 1 73.68 Breast Cancer 1 35.84 Malignant Neoplastic Disease 1 31.88 Arthritis 9 28.72 INFLAMMATION 15 25.00 Pain 2 25.00 Pressure And Volume Under Development 1 25.00 Increased Venous Pressure Under Development 1 25.00 Disease 5 13.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This is supported by our results showing that siRNA-mediated knockdown of MKK3 significantly inhibited the IL-1?

Negative_regulation (knockdown) of MKK3

1) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.54 Pain Relevance 0.27

Phosphoinositide 3-kinase (PI3K), tyrosine kinase of the epidermal growth factor receptor (EGFR), and mitogen activated protein kinase kinases (MEK) inhibitors were also tested.

Negative_regulation (inhibitors) of MEK

2) Confidence 0.07 Published 2004 Journal J. Cell. Physiol. Section Abstract Doc Link 15281091 Disease Relevance 0 Pain Relevance 0.35

General Comments

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