INT120446

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 32
Total Number 35
Disease Relevance 16.30
Pain Relevance 18.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
microglial cells 8
macrophages 1
grey matter 1
spinal cords 1
stomach 1
Cnr2 (Mus musculus)
Cnr2 - H316Y (1)
Pain Link Frequency Relevance Heat
agonist 438 100.00 Very High Very High Very High
Cannabinoid 344 100.00 Very High Very High Very High
Cannabinoid receptor 130 100.00 Very High Very High Very High
opioid receptor 36 99.98 Very High Very High Very High
alcohol 75 99.96 Very High Very High Very High
Neuropathic pain 69 99.84 Very High Very High Very High
Spinal cord 208 99.78 Very High Very High Very High
antinociception 18 99.76 Very High Very High Very High
antagonist 88 99.64 Very High Very High Very High
Multiple sclerosis 402 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 97 99.84 Very High Very High Very High
Nociception 38 99.60 Very High Very High Very High
Demyelinating Disease 297 99.54 Very High Very High Very High
INFLAMMATION 248 99.40 Very High Very High Very High
Motor Neuron Diseases 176 98.94 Very High Very High Very High
Vomiting 5 98.80 Very High Very High Very High
Targeted Disruption 72 98.48 Very High Very High Very High
Pain 148 98.24 Very High Very High Very High
Stress 100 97.72 Very High Very High Very High
Neurodegenerative Disease 64 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CB2 receptor-selective agonist AM1241 produces antinociceptive effects that are antagonized by CB2, but not CB1, receptor-selective antagonists, suggesting that activation of CB2 receptors results in antinociception.
Positive_regulation (activation) of CB2 associated with antinociception, antagonist, agonist and antinociceptive
1) Confidence 0.70 Published 2006 Journal Pain Section Abstract Doc Link 16563625 Disease Relevance 0.23 Pain Relevance 0.72
In addition, this study provides experimental evidence that also the activation of CB2 receptors is able to reduce cholinergic neurotransmission in the mouse stomach.
Positive_regulation (activation) of CB2 in stomach
2) Confidence 0.67 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17656103 Disease Relevance 0 Pain Relevance 0.44
Delta9-Tetrahydrocannabinol (Delta9-THC) and (-)-cannabidiol are major constituents of the Cannabis sativa plant with different pharmacological profiles: (-)-Delta9-tetrahydrocannabinol, but not (-)-cannabidiol, activates cannabinoid CB1 and CB2 receptors and induces psychoactive and peripheral effects.
Positive_regulation (activates) of CB2 associated with cannabis and cannabinoid
3) Confidence 0.67 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15588739 Disease Relevance 0.15 Pain Relevance 0.24
Here we demonstrate that a high incidence of (Q63R) but not (H316Y) polymorphism in the CB2 gene was found in Japanese depressed subjects.
Positive_regulation (incidence) of CB2 gene (H316Y)
4) Confidence 0.50 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2241668 Disease Relevance 0.70 Pain Relevance 0.64
Further, they confirm the potential therapeutic relevance of CB2 cannabinoid receptors for the treatment of acute pain.
Positive_regulation (relevance) of CB2 associated with cannabinoid receptor and acute pain
5) Confidence 0.50 Published 2006 Journal Pain Section Abstract Doc Link 16563625 Disease Relevance 0.25 Pain Relevance 0.79
These data strongly suggest that AM1241 produces antinociception in vivo by activating CB2 cannabinoid receptors.
Positive_regulation (activating) of CB2 associated with antinociception and cannabinoid receptor
6) Confidence 0.50 Published 2006 Journal Pain Section Abstract Doc Link 16563625 Disease Relevance 0.16 Pain Relevance 0.88
These results suggest that the activation of central, but not peripheral, cannabinoid CB2 receptors play an important role in reducing mechanical allodynia in a mouse model of neuropathic pain.
Positive_regulation (activation) of cannabinoid CB2 associated with allodynia, cannabinoid and neuropathic pain
7) Confidence 0.47 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18279850 Disease Relevance 0.67 Pain Relevance 1.11
Behavioral effects of CB2-R activation and blockade
Positive_regulation (activation) of CB2-R
8) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.27 Pain Relevance 0.32
The experiments reported here further test the hypothesis that CB2 receptor activation inhibits nociception.
Positive_regulation (activation) of CB2 associated with nociception
9) Confidence 0.47 Published 2006 Journal Pain Section Abstract Doc Link 16563625 Disease Relevance 0.31 Pain Relevance 0.92
Stimulation of CB2 inhibits functional CD40 signaling in microglial cells
Positive_regulation (Stimulation) of CB2 in microglial cells
10) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.12 Pain Relevance 0.23
To examine the functional consequences of CB2 agonist treatment on CD40 expression, we stimulated mouse primary microglial cells with either IFN-?
Spec (examine) Positive_regulation (treatment) of CB2 in microglial cells associated with agonist
11) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.14 Pain Relevance 0.19
Finally, we showed that CB2 activation by JWH-015 markedly attenuated CD40-mediated inhibition of microglial phagocytosis of A?
Positive_regulation (activation) of CB2
12) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.11 Pain Relevance 0.37
Taken together, these findings suggest that stimulation of CB2 decreases CD40 expression on primary cultured microglial cells.


Positive_regulation (stimulation) of CB2 in microglial cells
13) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.08
Accordingly, we examined the effects of CB2 stimulation on STAT1 phosphorylation, in the same dose range mentioned above, on primary microglial cells treated with IFN-?
Spec (examined) Positive_regulation (stimulation) of CB2 in microglial cells
14) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.21
Chronic treatment with CB2-R agonist JWH015 enhanced alcohol consumption in stressed but not in control mice.
Positive_regulation (enhanced) of CB2-R associated with agonist and alcohol
15) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.54 Pain Relevance 0.77
Many data reveal that cannabinoids mediate suppression of inflammation in vitro and in vivo through stimulation of cannabinoid receptor 2 (CB2).


Positive_regulation (stimulation) of cannabinoid receptor 2 associated with cannabinoid receptor, inflammation and cannabinoid
16) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.77 Pain Relevance 0.55
Many data reveal that cannabinoids mediate suppression of inflammation in vitro and in vivo through stimulation of cannabinoid receptor 2 (CB2).


Positive_regulation (stimulation) of CB2 associated with cannabinoid receptor, inflammation and cannabinoid
17) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.77 Pain Relevance 0.55
Stimulation of CB2 inhibits IFN-?
Positive_regulation (Stimulation) of CB2
18) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.04
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

Background

Positive_regulation (Stimulation) of cannabinoid receptor 2 associated with cannabinoid receptor
19) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Title Doc Link PMC1352348 Disease Relevance 0.82 Pain Relevance 0.52
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

Background

Positive_regulation (Stimulation) of CB2 associated with cannabinoid receptor
20) Confidence 0.42 Published 2005 Journal J Neuroinflammation Section Title Doc Link PMC1352348 Disease Relevance 0.82 Pain Relevance 0.52

General Comments

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