INT120823

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.71
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adcyap1) extracellular space (Adcyap1) extracellular region (Adcyap1)
Anatomy Link Frequency
neurons 6
pituitary 4
astrocytes 4
tail 2
Adcyap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 64 100.00 Very High Very High Very High
cytokine 10 100.00 Very High Very High Very High
intrathecal 5 99.98 Very High Very High Very High
tail-flick 1 99.84 Very High Very High Very High
allodynia 2 98.78 Very High Very High Very High
Glutamate 64 97.64 Very High Very High Very High
Chronic pancreatitis 2 96.84 Very High Very High Very High
noradrenaline 1 93.28 High High
antagonist 26 92.08 High High
Pain 7 90.48 High High
Disease Link Frequency Relevance Heat
Autoimmune Disease 39 99.12 Very High Very High Very High
Pancreatitis 12 98.80 Very High Very High Very High
Neuropathic Pain 5 98.78 Very High Very High Very High
Dementia 27 97.80 Very High Very High Very High
Neurodegenerative Disease 17 97.72 Very High Very High Very High
Nervous System Injury 2 94.08 High High
Ganglion Cysts 24 92.00 High High
Nociception 14 91.68 High High
Cognitive Disorder 3 91.20 High High
INFLAMMATION 53 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice.
Positive_regulation (Over-expression) of Gene_expression (Over-expression) of PACAP in pituitary associated with pancreatitis and cytokine
1) Confidence 0.68 Published 2009 Journal J. Pharmacol. Sci. Section Title Doc Link 19672038 Disease Relevance 0.79 Pain Relevance 0.26
In the early phase, PACAP produced an increase of tail flick latency.
Positive_regulation (increase) of Gene_expression (produced) of PACAP in tail associated with tail-flick
2) Confidence 0.44 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15518901 Disease Relevance 0.39 Pain Relevance 0.78
The NMDA-induced allodynia in PACAP-/- mice was reproduced by simultaneous intrathecal injection of PACAP with NMDA.
Positive_regulation (injection) of Gene_expression (injection) of PACAP associated with allodynia and intrathecal
3) Confidence 0.44 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15317855 Disease Relevance 0.84 Pain Relevance 0.94
Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice.
Positive_regulation (pancreatic) of Gene_expression (Over-expression) of pituitary adenylate cyclase-activating polypeptide in pituitary associated with pancreatitis and cytokine
4) Confidence 0.43 Published 2009 Journal J. Pharmacol. Sci. Section Title Doc Link 19672038 Disease Relevance 0.79 Pain Relevance 0.26
Similarly, microinjections of PACAP into the SCN region in vivo can cause phase shifts [23,25-27].
Positive_regulation (microinjections) of Gene_expression (microinjections) of PACAP
5) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.08 Pain Relevance 0.25
Fronto-temporal dementia (FTD) is a neurodegenerative disease in which a vascular component is suggested and immunoreactivity of Bax, a proapoptotic protein regulated in part by PACAP/VIP in astrocytes, suggests a role for autoimmunity in the pathology of FTD.44 Astrogliosis in FTD corresponds with SPECT hypoperfusion, suggesting that astrocyte disruption may be related to disturbances of cerebral perfusion in FTD.45 Cognitive dysfunction is associated with reduced cerebral blood flow in different types of dementia.46 Moreover VRS dilatation associated with microvessel abnormality may contribute to the diagnosis of vascular dementias.47 Changes in social behavior occur in cerebrovascular comprise and may result from an FTD-like syndrome.48 Similarly, reduction in cortical blood flow has been identified in CFS patients;49,50 however these findings were not replicated in a study of twins with CFS.51 FTD however is recognized in ALS.91
Positive_regulation (by) of Gene_expression (/) of PACAP in astrocytes associated with chronic fatigue syndrome, vascular dementia, cognitive disorder, autoimmune disease, dementia, syndrome, neurodegenerative disease and motor neuron diseases
6) Confidence 0.35 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.63 Pain Relevance 0.13
Fronto-temporal dementia (FTD) is a neurodegenerative disease in which a vascular component is suggested and immunoreactivity of Bax, a proapoptotic protein regulated in part by PACAP/VIP in astrocytes, suggests a role for autoimmunity in the pathology of FTD.44 Astrogliosis in FTD corresponds with SPECT hypoperfusion, suggesting that astrocyte disruption may be related to disturbances of cerebral perfusion in FTD.45 Cognitive dysfunction is associated with reduced cerebral blood flow in different types of dementia.46 Moreover VRS dilatation associated with microvessel abnormality may contribute to the diagnosis of vascular dementias.47 Changes in social behavior occur in cerebrovascular comprise and may result from an FTD-like syndrome.48 Similarly, reduction in cortical blood flow has been identified in CFS patients;49,50 however these findings were not replicated in a study of twins with CFS.51 FTD however is recognized in ALS.91
Positive_regulation (by) of Gene_expression (astrocytes) of PACAP in astrocytes associated with chronic fatigue syndrome, vascular dementia, cognitive disorder, autoimmune disease, dementia, syndrome, neurodegenerative disease and motor neuron diseases
7) Confidence 0.35 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.64 Pain Relevance 0.13
VNs,

such as PACAP and VIP, exert potent effects in metabolism as they have a vital

Positive_regulation (as) of Gene_expression (VNs) of PACAP associated with neuropeptide
8) Confidence 0.33 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2643053 Disease Relevance 0.27 Pain Relevance 0.09
PACAP enhanced excitatory synaptic transmission measured in mouse SCN neurons
Positive_regulation (transmission) of Gene_expression (transmission) of PACAP in neurons
9) Confidence 0.32 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.14 Pain Relevance 0.17
PACAP enhanced AMPA currents and AMPA-evoked Ca2+ transients in rat SCN neurons
Positive_regulation (enhanced) of Gene_expression (currents) of PACAP in neurons
10) Confidence 0.32 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.04
PACAP enhanced excitatory synaptic transmission measured in mouse SCN neurons
Positive_regulation (enhanced) of Gene_expression (transmission) of PACAP in neurons
11) Confidence 0.32 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0.14 Pain Relevance 0.17

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