INT120828

From wiki-pain
Revision as of 12:15, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 18.01
Pain Relevance 12.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
fibroblasts 3
monocytes 3
epithelial cells 2
myoblasts 2
T cell 2
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 395 100.00 Very High Very High Very High
Inflammation 295 100.00 Very High Very High Very High
Fibrositis 26 99.84 Very High Very High Very High
Morphine 12 99.04 Very High Very High Very High
agonist 65 98.68 Very High Very High Very High
analgesia 6 98.68 Very High Very High Very High
chemokine 477 98.08 Very High Very High Very High
Spinal cord 2 96.96 Very High Very High Very High
tolerance 17 96.92 Very High Very High Very High
Hyperalgesia 8 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 350 100.00 Very High Very High Very High
Fibromyalgia 20 99.84 Very High Very High Very High
Infection 140 97.76 Very High Very High Very High
Eye Disease 130 97.56 Very High Very High Very High
Hyperalgesia 9 96.48 Very High Very High Very High
Neuropathic Pain 7 95.76 Very High Very High Very High
Syndrome 82 94.92 High High
Mycobacterial Infection 19 94.52 High High
Disorders Of The Lacrimal System 48 92.76 High High
Cancer 146 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, heat-killed bacteria did not induce CXCL10 secretion.
Localization (secretion) of CXCL10
1) Confidence 0.68 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 18037659 Disease Relevance 0.45 Pain Relevance 0.50
Human conjunctival epithelial cells in vitro secrete significantly increased amounts of IP-10/CXCL10 when stimulated by TNF-?
Localization (secrete) of IP-10 in epithelial cells
2) Confidence 0.60 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.40 Pain Relevance 0.29
Human conjunctival epithelial cells in vitro secrete significantly increased amounts of IP-10/CXCL10 when stimulated by TNF-?
Localization (secrete) of CXCL10 in epithelial cells
3) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 1.41 Pain Relevance 0.29
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
Localization (secreted) of CXCL10 in monocytes
4) Confidence 0.51 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.59
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
Localization (secreted) of IP-10 in monocytes
5) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.59
Studies in mice revealed additionally that CXCL10 is secreted early (e.g., earlier than CXCL9, which we did not detect at the same levels in the serum as CXCL10) [73], and stimulates T cell proliferation [74].
Localization (secreted) of CXCL10 in T cell
6) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.27 Pain Relevance 0.05
We therefore tested whether dsRNA may directly induce CXCL10 secretion by highly purified rhesus macaque DCs in vitro.
Localization (secretion) of CXCL10
7) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.07 Pain Relevance 0.05
Studies in mice revealed additionally that CXCL10 is secreted early (e.g., earlier than CXCL9, which we did not detect at the same levels in the serum as CXCL10) [73], and stimulates T cell proliferation [74].
Localization (secreted) of CXCL10 in T cell
8) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.28 Pain Relevance 0.05
may in turn induce CXCL10 secretion by infected cells, thus perpetuating the immune cascade responsible for these endocrine disorders.
Localization (secretion) of CXCL10
9) Confidence 0.37 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 1.43 Pain Relevance 0
T cell co-cultures were a rich source of chemokines with known functions in acute infections, as shown for CXCL8 (IL-8) and CCL2 (MCP-1), which target neutrophils and monocytes, respectively, and CXCL10 (IP-10), one of three IFN-?
Localization (one) of IP-10 in monocytes associated with chemokine and infection
10) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.33 Pain Relevance 0.28
The CXCL10 was localized mainly in the cytoplasm of pancreatic acinar cells and expression increased from grade I to grade II and declined in grade III while no expression was recorded in normal.
Localization (localized) of CXCL10 in acinar cells
11) Confidence 0.31 Published 2007 Journal Pancreatology Section Body Doc Link 17912012 Disease Relevance 0.08 Pain Relevance 0
Furthermore, myoblasts can secrete MCP-1, eotaxin, and IP-10, while treatment with MCP-1 caused secretion of IL-1beta, eotaxin and IP-10.
Localization (secretion) of IP-10 in myoblasts
12) Confidence 0.30 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18535166 Disease Relevance 1.16 Pain Relevance 0.73
The secretion of CXCL10 by these DC seems to play a major role in the induction of specific CTL and their homing to the brain [105].
Localization (secretion) of CXCL10 in brain
13) Confidence 0.30 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 0.44 Pain Relevance 0.04
Furthermore, myoblasts can secrete MCP-1, eotaxin, and IP-10, while treatment with MCP-1 caused secretion of IL-1beta, eotaxin and IP-10.
Localization (secrete) of IP-10 in myoblasts
14) Confidence 0.23 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18535166 Disease Relevance 1.15 Pain Relevance 0.72
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
Localization (secreted) of CXCL10 in fibroblasts
15) Confidence 0.17 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.59
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
Localization (secreted) of IP-10 in fibroblasts
16) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.59
and TNF (with the exception for RANTES and IP-10), even though it potentiates the proinflammatory activities of TNF or IL-1?.
Neg (exception) Localization (exception) of IP-10
17) Confidence 0.16 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.65 Pain Relevance 0.07
Effects of anti-TWEAK mAbs on the secretion of IL-8, MMP-1, PGE2, IL-6, IP-10 and RANTES by dermal fibroblasts and synoviocytes stimulated by hTWEAK, alone or in association with TNF or IL-1?
Localization (secretion) of IP-10 in fibroblasts
18) Confidence 0.15 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.05 Pain Relevance 0.11
Moreover, blocking anti-TNF antibodies were inactive in the secretion of IL-8, MMP-1, PGE2, RANTES and IP-10 induced by TWEAK, ruling out any involvement of TNF in TWEAK activity.
Localization (secretion) of IP-10
19) Confidence 0.15 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.19 Pain Relevance 0.04
T cell co-cultures were a rich source of chemokines with known functions in acute infections, as shown for CXCL8 (IL-8) and CCL2 (MCP-1), which target neutrophils and monocytes, respectively, and CXCL10 (IP-10), one of three IFN-?
Localization (one) of IP-10 in neutrophils associated with chemokine and infection
20) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.33 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox