INT12085

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.90
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
platelet 4
nucleus 2
mononuclear cell 2
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 26 100.00 Very High Very High Very High
Morphine 8 99.98 Very High Very High Very High
aspirin 100 98.86 Very High Very High Very High
opiate 1 97.76 Very High Very High Very High
fibrosis 7 92.24 High High
Inflammation 25 90.88 High High
Pain 12 78.88 Quite High
narcan 1 55.88 Quite High
Mechanotransduction 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 5 99.76 Very High Very High Very High
Intervertebral Disk Degeneration 9 98.96 Very High Very High Very High
Hepatitis B Virus Infection 10 97.56 Very High Very High Very High
Hepatitis C Virus Infection 72 97.20 Very High Very High Very High
Metastasis 28 94.32 High High
Atherosclerosis 6 93.92 High High
Infection 29 93.64 High High
Cancer 98 93.28 High High
Breast Cancer 6 91.76 High High
Hypercalcemia 5 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the dose-dependent effect of TGF-?
Positive_regulation (dependent) of Localization (effect) of TGF
1) Confidence 0.42 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636034 Disease Relevance 0.25 Pain Relevance 0
g/L, This range is very important in the future therapeutic applications of the TGF-?
Positive_regulation (important) of Localization (applications) of TGF
2) Confidence 0.42 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636034 Disease Relevance 0.26 Pain Relevance 0
Morphine potentiates transforming growth factor-beta release from human peripheral blood mononuclear cell cultures.
Positive_regulation (potentiates) of Localization (release) of transforming growth factor-beta in mononuclear cell associated with morphine
3) Confidence 0.39 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1625199 Disease Relevance 0.17 Pain Relevance 0.68
COX-1, the major target of ASA, regulates exocytosis of platelet granules and it might mediate VSMC secretion of TGF-?
Spec (might) Positive_regulation (mediate) of Localization (secretion) of TGF in platelet associated with aspirin
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.28 Pain Relevance 0.38
These complexes then migrate to the nucleus where they activate a series of TGF- ?
Positive_regulation (activate) of Localization (series) of TGF in nucleus
5) Confidence 0.32 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.56 Pain Relevance 0
As the bone is resorbed, the release of transforming growth factor beta (TGF-ß) from the bone matrix contributes to further increase PTHrP expression [5].
Positive_regulation (increase) of Localization (release) of TGF
6) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 1.48 Pain Relevance 0.08
However, a laboratory analysis of human PRP samples demonstrated increased concentrations of PDGF, TGFbeta, VEGF, and EGF, while not showing an increase in IGF-1 [25].
Positive_regulation (increased) of Localization (concentrations) of TGFbeta
7) Confidence 0.13 Published 2008 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2682411 Disease Relevance 0.22 Pain Relevance 0.05
ROS play also an important role in fibrogenesis throughout increasing platelet-derived growth factor [56] or the secretion of profibrotic cytokines, such as TGF-?.
Positive_regulation (increasing) of Localization (secretion) of TGF in platelet associated with fibrosis and cytokine
8) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.69 Pain Relevance 0.21

General Comments

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