INT120851

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.05
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NFKB1, TNF) nucleoplasm (NFKB1) mitochondrion (NFKB1)
intracellular (TNF) extracellular matrix organization (TNF) cytoplasm (NFKB1)
Anatomy Link Frequency
adipocytes 2
NFKB1 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 23 96.56 Very High Very High Very High
cytokine 6 85.64 High High
anesthesia 3 76.60 Quite High
Kinase C inhibitor 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 68 99.32 Very High Very High Very High
INFLAMMATION 21 96.56 Very High Very High Very High
Necrosis 3 79.76 Quite High
Cancer 3 79.40 Quite High
Congenital Anomalies 2 64.76 Quite High
Overweight 1 52.96 Quite High
Diabetes Mellitus 2 47.12 Quite Low
Metabolic Syndrome 2 45.24 Quite Low
Insulin Resistance 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.
NFkappaB Positive_regulation (promote) of Localization (secretion) of TNF-alpha
1) Confidence 0.04 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.48 Pain Relevance 0.25
However, we demonstrated that PRL, by itself or in combination with LPS, causes an increase in the binding activity of the transcription factors nuclear factor-kappaB (NFkappaB) and interferon regulatory factor-1 (IRF-1), which are known to promote TNF-alpha and IL-12 secretion.
nuclear factor-kappaB Positive_regulation (promote) of Localization (secretion) of TNF-alpha
2) Confidence 0.03 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.48 Pain Relevance 0.25
In the first part of this study, we identified the TLR4 signalling pathways activated by LPS (NFkappaB and p38 MAP Kinase), which lead to the secretion of TNFalpha by mature human adipocytes.
NFkappaB Positive_regulation (lead) of Localization (secretion) of TNFalpha in adipocytes associated with obesity
3) Confidence 0.01 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 1.09 Pain Relevance 0.12

General Comments

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