INT120860

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.84
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
molecular_function (Col1a1) cytoplasm (Col1a1)
Anatomy Link Frequency
PSCs 4
hindlimb 4
tendons 2
platelet 2
Col1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 75 100.00 Very High Very High Very High
Inflammation 5 98.04 Very High Very High Very High
cytokine 4 95.64 Very High Very High Very High
fibrosis 5 84.88 Quite High
Chronic pancreatitis 5 83.92 Quite High
COX-2 inhibitor 1 82.20 Quite High
anesthesia 1 81.28 Quite High
imagery 8 73.40 Quite High
Angina 1 67.32 Quite High
Dopamine 6 62.08 Quite High
Disease Link Frequency Relevance Heat
Stress 172 100.00 Very High Very High Very High
INFLAMMATION 6 98.04 Very High Very High Very High
Hypertrophy 5 97.04 Very High Very High Very High
Primary Sclerosing Cholangitis 4 92.88 High High
Proteinuria 2 92.84 High High
Nephritis 4 89.44 High High
Intervertebral Disk Degeneration 39 89.32 High High
Fibrosis 6 80.28 Quite High
Rotator Cuff Tears 30 77.00 Quite High
Obesity 2 75.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of type I collagen, osteocalcin and MMPs 2 and 13 increased toward week 2 and decreased thereafter, whereas the expression of MMP 8 was the highest on day 1.
Positive_regulation (increased) of Gene_expression (expression) of type I collagen associated with metalloproteinase
1) Confidence 0.44 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.37
Although the expression of collagen type I in the 7-day stress group did not significantly increase compared with that of the control group, such expression significantly increased as the duration of stress exposure increased to 28 days.
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of collagen type I associated with stress
2) Confidence 0.31 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 1.05 Pain Relevance 0.06
RESULTS: High glucose concentrations significantly increased PSC proliferation, alpha-SMA expression, and collagen type I production in PSCs.
Positive_regulation (increased) of Gene_expression (production) of collagen type I in PSCs
3) Confidence 0.27 Published 2007 Journal Pancreas Section Body Doc Link 17414061 Disease Relevance 0.16 Pain Relevance 0
Nicorandil significantly prevented the overexpression of type I collagen, fibronectin, transforming growth factor (TGF)-beta, and platelet-derived growth factor (PDGF) mRNA.
Positive_regulation (overexpression) of Gene_expression (overexpression) of type I collagen in platelet
4) Confidence 0.27 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19721333 Disease Relevance 1.17 Pain Relevance 0.07
Moreover, pressure significantly promoted activated TGF-beta1 secretion, collagen type I mRNA expression, and collagen secretion.
Positive_regulation (promoted) of Gene_expression (expression) of collagen type I mRNA
5) Confidence 0.24 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.05 Pain Relevance 0.18
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Positive_regulation (increase) of Gene_expression (expression) of COLIA1
6) Confidence 0.19 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.70 Pain Relevance 0
This may be due to increased type-I collagen expression resulting in increased the matrix density, and altered cell behavior resulting in a more organized collagen matrix.
Positive_regulation (increased) of Gene_expression (expression) of type-I collagen
7) Confidence 0.09 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.06 Pain Relevance 0
Karnousou et al. and Olesen et al. showed increased collagen type 1 synthesis in the peritendineum of Achilles tendons after prolonged mechanical loading [33,34].
Positive_regulation (increased) of Gene_expression (synthesis) of collagen type 1 in tendons
8) Confidence 0.06 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.53 Pain Relevance 0.35
In accordance with data showing increased matrix deposition and organization (Figs. 4 and 5), expression of type-I collagen was increased in tissues from IGF-I treated ambulatory (p = 0.0018) and unloaded (p = 0.0006) animals and GH+IGF-I treated unloaded tissue (p = 0.0005; Figs. 6A and 6B).
Positive_regulation (increased) of Gene_expression (expression) of type-I collagen
9) Confidence 0.06 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.05 Pain Relevance 0.04
Force, stress, and modulus values in tissues from hindlimb unloaded animals receiving IGF-I or GH+IGF-I exceeded (or were equivalent to) values in tissues from ambulatory animals receiving only saline with greatly improved structural organization and significantly increased type-I collagen expression.
Positive_regulation (increased) of Gene_expression (expression) of type-I collagen in hindlimb associated with stress
10) Confidence 0.06 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1851714 Disease Relevance 0.26 Pain Relevance 0
Adenovirus-mediated expression of dominant negative Smad2/3 inhibited the increase in expression of COX-2, alpha-SMA, and collagen-1 mediated by TGF-beta1 in activated PSCs.
Positive_regulation (increase) of Gene_expression (expression) of collagen-1 in PSCs
11) Confidence 0.05 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.42 Pain Relevance 0.29
Addition of IGF-I significantly improved maximum force and ultimate stress in tissues from both ambulatory and hindlimb unloaded animals with significant increases in matrix organization and type-I collagen expression.
Positive_regulation (increases) of Gene_expression (expression) of type-I collagen in hindlimb associated with stress
12) Confidence 0.05 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1851714 Disease Relevance 0.39 Pain Relevance 0

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