INT120861

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.24
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Acta2) cytoplasm (Acta2)
Anatomy Link Frequency
PSCs 8
Acta2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 2 96.68 Very High Very High Very High
cytokine 6 89.76 High High
Chronic pancreatitis 10 79.92 Quite High
fibrosis 7 75.28 Quite High
Inflammatory response 2 74.64 Quite High
Inflammation 1 50.00 Quite Low
Kinase C 1 50.00 Quite Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 7 95.40 Very High Very High Very High
Pancreatitis 12 79.92 Quite High
INFLAMMATION 3 74.24 Quite High
Fibrosis 8 72.72 Quite High
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Hyperglycemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DA-9601 decreased the expressions of alpha-SMA and type I collagen in cultured pancreatic stellate cells.
Negative_regulation (decreased) of Gene_expression (expressions) of alpha-SMA in stellate cells
1) Confidence 0.11 Published 2005 Journal Pancreatology Section Body Doc Link 15849487 Disease Relevance 0.16 Pain Relevance 0
NS-398 also inhibited the enhancement of alpha-SMA expression by TGF-beta1, IL-1beta, and IL-6 in activated PSCs.
Negative_regulation (inhibited) of Gene_expression (expression) of alpha-SMA in PSCs
2) Confidence 0.00 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.42 Pain Relevance 0.32
Moreover, dominant negative Smad2/3 expression attenuated the expression of COX-2 and alpha-SMA enhanced by IL-1beta and IL-6.
Negative_regulation (attenuated) of Gene_expression (expression) of alpha-SMA
3) Confidence 0.00 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.40 Pain Relevance 0.26
High glucose concentrations activated protein kinase C (PKC) in PSCs, and PKC inhibitor GF109203X inhibited glucose-stimulated PSC proliferation, alpha-SMA expression, and collagen secretion.
Negative_regulation (inhibited) of Gene_expression (expression) of alpha-SMA in PSCs
4) Confidence 0.00 Published 2007 Journal Pancreas Section Body Doc Link 17414061 Disease Relevance 0.15 Pain Relevance 0
Treatment of PSCs with an MEK inhibitor and p38 MAPK inhibitor suppressed pressure-induced cell proliferation and alpha-SMA expression, respectively.
Negative_regulation (suppressed) of Gene_expression (expression) of alpha-SMA in PSCs
5) Confidence 0.00 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.11 Pain Relevance 0.19

General Comments

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